Multiphase Bioreactor Design

DW dry weight ECP extracellular polysaccharide FW fresh weight OTR oxygen transfer rate OUR oxygen uptake rate RDR rotating drum ...

Croughan, M.S., Sayre, E.S. and Wang, D.I.C. (1989) Viscous reduction of turbulent damage in animal cell culture. Biotechnology ...

by T.-J.Fu, G.Singh and W.R.Curtis, pp. 195–213. New York: Kluwer Academic/Plenum Publishers. Hanagata, N., Ito, A., Uehara, H., ...

Keßler, M., ten Hoopen, H.J.G. and Furusaki, S. (1999) The effect of aggregate size on the production of ajmalicine and tryptami ...

Namdev, P.K. and Dunlop, E.H. (1995) Shear sensitivity of plant cells in suspension. Applied Biochemistry and Biotechnology, 54, ...

Shamakov, N.V. et al. (1991) Large-scale ginseng cultivation in suspension II. Soviet Biotechnology, 1, 41–44. Shuler, M.L. (199 ...

Takei, A., Shoga, Y., Hama, M., Honda, Y., Sugimura, Y. and Otsuji, K. (1995) Production of polysaccharides by liquid cultures o ...

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CHAPTER FIFTEEN LETHAL EFFECTS OF BUBBLES IN ANIMAL-CELL CULTURE DIRK E.MARTENS, MICHEL F.MULLER, CORNELIS D.DE GOOIJER AND JOHA ...

and large-scale (>1000 litre) production, suspension cultures are being used mostly. The major concern in scale-up of suspens ...

In this chapter empirical models describing the specific death rate due to sparging as a function of reactor parameters are firs ...

PVA 0.1 47 65 2 1.24 Michaels 1995b 0.1 48.7 71.5 Chattopadhyay 1995b PVP 0.1 53 61.1 41600 0.25 Michaels 1995b PEG 8000 0.1 52 ...

reactor diameter. In Figure 15.1 an example is shown on the relation between the first- order death-rate constant and the gas-fl ...

Figure 15.1 First-order death-rate constant in a small bubble column as a function of the air-flow rate and reciprocal column he ...

the findings of Tramper et al. (1988), who found that Vd is proportional to the bubble volume. It also differs from the findings ...

Parameter Tramper et al. (1988) Wu and Goosen (1995a) Vd0(m^3 ) −5 (−176+166) 10−^13 −1 (−360+358) 10−^13 k 0.001 (−0.005+0.008) ...

(9) This equation equals equation (3) for the hypothetical-killing-volume theory, with the killing volume being proportional to ...

Table 15.4 Shear sensitivity of different cells under different conditions. Presented is the lowest shear stress used in the ref ...

protection when cells are exposed to laminar shear stresses of 8 N.m^2 for less than 20 minutes. Eyl et al. (1992) reported that ...

30% of measured cell disruption, which ranged from 5 to 100%. For turbulent flow in a capillary good agreement was also obtained ...