Multiphase Bioreactor Design

Figure 14.2 Rheological profiles for batch cultures of (a) M. citrifolia (Cusack and Kieran, 1998) and (b) P. somniferum (Curtis ...

batch cycle (Kieran et al., 1993). However, the osmotic potential of the medium, which is predominantly determined by salt and s ...

conditions and growth phase, but are generally of the order of 10−^6 g O 2 (g DW)−^1 s−^1. Maximum values typically occur early ...

recorded under high shear conditions, suggesting increased cellular maintenance requirements in cells under hydrodynamic stress. ...

impeller agitation rate, and include rotational speed (N) and impeller tip speed (πND). Kobayashi et al. (1993) successfully use ...

be as high as 100 times the tank-averaged value. In the remainder of the vessel, the local dissipation rate may fall to 0.25. In ...

somniferum Ad/Ar: 1 (1992) Datura stramonium 1.2L ALR Ad/Ar: 0.69 Qg: 0.69 vvm N/A 0.05 Ballica & Ryu (1993) Chenopodium 20 ...

Figure 14.4 Sustained damage in D. carota (Dunlop et al., 1994), M. citrifolia (Kieran et al., 1994; MacLoughlin et al., 1998) a ...

The shaded regions for the Atropa belladonna data reflect the displacement of the data depending on whether total cumulative ene ...

15–20 g DW L−^1 (Hashimoto and Azechi, 1988; Ritterhaus et al., 1990; Hibino and Ushiyama, 1999). In most practical applications ...

estimate Njs, Singh and Curtis (1994a) examine the interactions between aggregate size and agitation conditions on scale-up; on ...

where kLa is frequently related to the operating conditions in a STR by correlations of the following form: (7) For ALRs, empiri ...

m−^3 (Figure 14.4), combined with a model proposed by Jüsten et al. (1998) for fungal mycelial breakage. The aeration rates of 0 ...

Multiphase bioreactor design 438 ...

Figure 14.5 Flow regime maps for (a) Rushton turbine (D=0.5T) and (b) upward-pumping, 6-blade, pitched- blade turbine (D=0.57). ...

between values of about 4 and 6. The stability of foam, once formed, is further enhanced by the presence of ECPs. As with all fe ...

through a combination of biological and processing strategies, or reducing process costs. A stainless steel, sterilisable biorea ...

Figure 14.6 Schematic diagram of a low cost bioreactor developed for plant cell suspension cultures. Redrawn, with permission, f ...

CONCLUSIONS Large-scale cultivation of plant cell suspensions for the production of valuable phytochemicals is certainly feasibl ...

continuous Two-stage batch – – Continuous (chemostat) – – Two-stage continuous – – Perfusion with cell retention – – with cell b ...