Drug Metabolism in Drug Design and Development Basic Concepts and Practice

Emergence of new technologies will further accelerate drug metabolism studies in both drug discovery and development. In drug di ...

Acknowledgments The authors would like to thank Dr. Matt McLean for reviewing the manuscript and providing valuable suggestions. ...

and L-739,010 to reactive intermediates that covalently bind to protein: the role of the 6,8-dioxabicyclo[3.2.1]octanyl moiety. ...

Dieckhaus CM, Fernandez-Metzler CL, King R, Krolikowski PH, Baillie TA. Negative ion tandem mass spectrometry for the detection ...

Hopfgartner G, Husser C, Zell M. Rapid screening and characterization of drug metabolites using a new quadrupole-linear ion trap ...

derivatization and on-line H/D exchange approaches. J Pharm Biomed Anal 2005;37:1–18. Liu DQ, Hop CE, Beconi MG, Mao A, Chiu SH. ...

Nassar AE, Talaat RE. Strategies for dealing with metabolite elucidation in drug discovery and development. Drug Discov Today 20 ...

Shen Z, Reed JR, Creighton M, Liu DQ, Tang YS, Hora DF, Feeney W, Szewczyk J, Bakhtiar R, Franklin RB, Vincent SH. Identificatio ...

Valaskovic GA, Utley L, Lee MS, Wu JT. Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass ...

Yang Z. Online hyphenated liquid chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry for drug metabolite an ...

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12 INTRODUCTION TO NMR AND ITS APPLICATION IN METABOLITE STRUCTURE DETERMINATION XIAOHUAHUANG,ROBERTPOWERS,ADRIENNETYMIAK, ROBER ...

In this chapter we provide a brief introduction to NMR theory and describe the most common experiments used for metabolite struc ...

The intensity of the NMR signal is extremely small when compared to all other types of spectroscopy due to the small energy gap ...

shift. This precessing process is captured as a free induction decay (FID) by monitoring the variation in an induced current in ...

5-gauss line by one-fourth, which needs to be shielded from personnel and other equipment, resulting in a significant reduction ...

TABLE 12.2 Common NMR hardware and its new developments. Conventional design New developments Advantages Magnet Super conducting ...

TABLE 12.3 Properties of common NMR spectral characteristics.Chemical shifts Coupling constants Integration Relaxation times Che ...

TABLE 12.3 ( Continued ) Chemical shifts Coupling constants Integration Relaxation times > d=( nsample nref )/ nref 10 6 ...

12.4.1 Chemical Shifts The electronic environment of a nucleus is determined by the spatial arrangement of adjacent atoms and el ...