Catalyzing Inquiry at the Interface of Computing and Biology
COMPUTATIONAL TOOLS 79 schemes).^56 Finally, because individual experiments can study only a few aspects of a brain region at on ...
80 CATALYZING INQUIRY Ecological databases also rely on metadata to improve interoperability and compatibility among disparate d ...
COMPUTATIONAL TOOLS 81 support a wider variety of queries and data types, but may be slower to gain adoption. Another effort to ...
82 CATALYZING INQUIRY Biologists use a variety of different data representations to help describe, examine, and understand data. ...
COMPUTATIONAL TOOLS 83 Other diagrammatic simulations of complex cell networks use tools such as the Diagrammatic Cell Language ...
84 CATALYZING INQUIRY 4.3.3 Automated Literature Searching, Still another form of data presentation is journal publication. It h ...
COMPUTATIONAL TOOLS 85 based on templates that matched specific linguistic structures to recognize and extract of protein inter- ...
86 CATALYZING INQUIRY Box 4.5 Selected Information Extraction Successes in Biology Besides the recognition of protein interactio ...
COMPUTATIONAL TOOLS 87 4.4 Algorithms for Operating on Biological Data, 4.4.1 Preliminaries: DNA Sequence as a Digital String, T ...
88 CATALYZING INQUIRY These comments should not be taken to mean that the abstraction of DNA into a digital string is cost- free ...
COMPUTATIONAL TOOLS 89 A significant computational aspect of this example is that since the general problem of identifying subgr ...
90 CATALYZING INQUIRY Regions of the genome that are not transcribed from DNA into RNA include biological signals (such as promo ...
COMPUTATIONAL TOOLS 91 that although “all 518 [kinase] genes are covered by some EST [Expressed Sequence Tag] sequence, and ~90% ...
92 CATALYZING INQUIRY 4.4.5 Sequence Alignment and Evolutionary Relationships, A remarkable degree of similarity exists among th ...
COMPUTATIONAL TOOLS 93 Alignments of gene and protein sequences from many different organisms are used to find diagnostic patter ...
94 CATALYZING INQUIRY species (S. paradoxus, S. mikatae, and S. bayanus).^105 This analysis resulted in significant revisions of ...
COMPUTATIONAL TOOLS 95 recombination, and smaller numbers of relatively recent mutations.^107 Examining the variation of gene or ...
96 CATALYZING INQUIRY are unlikely to be separated by recombination that takes place during reproduction. Further, only a relati ...
COMPUTATIONAL TOOLS 97 Finally, in early 2005, National Geographic and IBM announced a collaboration known as the the Genographi ...
98 CATALYZING INQUIRY Many analytic techniques have been developed and applied to the problem of revealing biologically signific ...
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