Catalyzing Inquiry at the Interface of Computing and Biology
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 139 5.4.2 Cell Biology and Physiology, 5.4.2.1 Cellul ...
140 CATALYZING INQUIRY There are many different tools for simulating and analyzing models of cellular systems (Table 5.1). More ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 141 An example of a cellular simulation environment i ...
142 CATALYZING INQUIRY transcription, translation, energy production, and phospholipid synthesis with only 127 genes. Most of th ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 143 pathway involved in the circadian rhythm of Synec ...
144 CATALYZING INQUIRY a concrete system of differential and algebraic equations. This experimental geometry may assume well- mi ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 145 Endy and Yin in using their T7 model to propose a ...
146 CATALYZING INQUIRY 5.4.2.2 Cell Cycle Regulation, Biological growth and reproduction depend ultimately on the cycle of DNA s ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 147 For understanding the dynamics of molecular regul ...
148 CATALYZING INQUIRY 5.4.2.3 A Computational Model to Determine the Effects of SNPs in Human Pathophysiology of Red Blood Cell ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 149 Clinical data taken from the published literature ...
150 CATALYZING INQUIRY 5.4.2.4.2 The Movement of Listeria Bacteria Alberts and Odell have developed a computational model of Lis ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 151 dates arbitrary geometries, explicit stochastic i ...
152 CATALYZING INQUIRY (^67) For purposes of the discussion in this subsection (Section 5.4.3.1), regulation refers to cis-regul ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 153 The computational model undoubtedly provides a co ...
154 CATALYZING INQUIRY The total number of genes involved is N, a number of order 30,000. The number of genes that regulate a g ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 155 (about 200). Such a result may be numerological c ...
156 CATALYZING INQUIRY widely believed to be a pathology of the hereditary apparatus. However, it has been clear for some time t ...
COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 157 If the correspondence between attractor and cell ...
158 CATALYZING INQUIRY ing decision logic, and executes stored programs [in the DNA] that guide cellular differentiation ex- ten ...
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