Catalyzing Inquiry at the Interface of Computing and Biology
COMPUTATIONAL TOOLS 99 a random order, each data point is selected. At each iteration, the nodes move closer to the selected dat ...
100 CATALYZING INQUIRY rely on training sets provided by the researchers, where the class membership of data is provided. Then, ...
COMPUTATIONAL TOOLS 101 4.4.8.2 A Contemporary Example: Protein Family Classification and Data Integration for Functional Analys ...
102 CATALYZING INQUIRY FIGURE 4.4 Integration of protein family, pathway, and genome context data for disease gene identificatio ...
COMPUTATIONAL TOOLS 103 4.4.9 Determination of Three-dimensional Protein Structure, One central problem of proteomics is that of ...
104 CATALYZING INQUIRY Protein structures predicted in high resolution can help characterize the biological functions of protein ...
COMPUTATIONAL TOOLS 105 can be divided into three areas depending on the similarity of the target protein to proteins of known s ...
106 CATALYZING INQUIRY Beyond studies of protein structure is the problem of describing a solvent environment (such as water) an ...
COMPUTATIONAL TOOLS 107 mass spectrometry, a peptide pair could be approximately labeled by its retention time in the column, an ...
108 CATALYZING INQUIRY been a source of qualitative insight.^140 While this is still true, there is growing interest in using im ...
COMPUTATIONAL TOOLS 109 Fluorescent speckle microscopy, a technique for quantitatively tracking the movement, assem- bly, and d ...
110 CATALYZING INQUIRY The discussion below focuses only on a narrow slice of the very general problem of biological imaging, as ...
COMPUTATIONAL TOOLS 111 FIGURE 4.5 Visualizations of mutant (left) and normal (right) mice embryos. CT values are inspected by m ...
112 CATALYZING INQUIRY benches. Similarly, a scanned image of a magazine page may contain text and graphics (e.g., a picture of ...
COMPUTATIONAL TOOLS 113 problems in image analysis can be solved, including image registration, shape analysis, and volume and a ...
114 CATALYZING INQUIRY and distributed across multiple resources can be compared reliably. Through the use of atlases and tools ...
COMPUTATIONAL TOOLS 115 potential inputs, and combinations of factors, and must be robust even in the face of invalid usage. The ...
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COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 117 117 5 BIOLOGICAL DISCOVERY 5 COMPUTATIONAL MODELI ...
118 CATALYZING INQUIRY Different fields of science have traditionally used models for different purposes; thus, the nature of th ...
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