Science - USA (2022-04-29)
native bromodeoxyuridine (BrdU) and rep- lication protein A (RPA) foci formation. Both approaches demonstrated elevated numbers ...
478 29 APRIL 2022¥VOL 376 ISSUE 6592 science.orgSCIENCE NT 1h 3h 6h 24h CAD ICAD-L p53 H3 IR (8Gy) Chromatin Fraction A TUNEL mC ...
SCIENCEscience.org 29 APRIL 2022¥VOL 376 ISSUE 6592 479 5000 10000 15000 20000 RFI 0 5 10 15 20 25 0 Time (min) mCherry- ICAD GF ...
(TUNEL) (Fig. 2B). Activation of the DNA dam- age response was noted by increased RPA association, ATR (ataxia telangiectasia an ...
checkpoint. We confirmed premature mitotic entry observed in the siRNA-based screen using individual siRNAs targeting CAD and IC ...
active CHK1 (fig. S10, A to E). CDK1 inhi- bition is required to restrict mitotic entry after IR. Additionally, activated CHK2 a ...
M. T. Dillon, J. S. Good, K. J. Harrington,Clin. Oncol. 26 , 257 – 265 (2014). A. Cieślar-Pobuda, Y. Saenko, J. Rzeszowska-Woln ...
is encoded by slow-acting neuropeptides in C fibers and their cognate excitatory G protein– coupled receptors (GPCRs) in laminae ...
NK1R—two markers expressed in distinct sub- sets of projection neurons—implicated in af- fective touch and pain, respectively ( ...
anxiety associated with handling. First, given that social isolation increases the urge for social touch and attachment ( 26 ), ...
2 days) using an unbiased two-chamber pleas- ant touch–conditioned place preference (PT- CPP) apparatus in which WT mice display ...
Neurophysiological features of PROKR2 neurons in response to varying stimuli To interrogate neural correlates of pleasant touch, ...
skin of mice was brushed at a slowly moving speed (18 to 22 cm/s); however, their firing became sluggish if the stroking speed w ...
C fiber inputs and GRP and GRPR neurons ( 22 , 25 ) (fig. S8, A to D). Notably, RTX treat- ment had no effect on PT-CPP (fig. S8 ...
Y. G. Sunet al.,Science 325 , 1531–1534 (2009). S. Chenet al.,Nat. Commun. 11 , 5074 (2020). E. B. Keverne, N. D. Martensz, B. ...
In situ observation of subcell deformation in zeolite channels ZSM-5 zeolites are composed of corner-sharing tetrahedral TO 4 (T ...
the C 6 plane of benzene molecules, and com- pressed alongDmin(8.31 ± 0.12 Å), with an aspect ratio of 1.176 (Fig. 1F). The diff ...
was a slow process that could be observed with iDPC-STEM imaging. To quantitatively describe the benzene desorption process, we ...
However, as more benzene was adsorbed, the flexibility of the pore channels decreased, and the shapes tended to resemble an elli ...
particular symmetry of the MFI framework gives it local flexibility and overall rigidity, which allows subcell deformation to ac ...
«
1
2
3
4
5
6
7
8
9
10
»
Free download pdf