Science - USA (2022-04-29)
SCIENCE science.org 29 APRIL 2022 • VOL 376 ISSUE 6592 469 science-based recommendations. Genetic and behavioral processes that ...
science.org SCIENCE INSIGHTS | LETTERS million tons of plastic waste will still be released to terrestrial and aquatic envi- ron ...
PHOTO: SUZANNE LONG/ALAMY STOCK PHOTO SCIENCE science.org 29 APRIL 2022 • VOL 376 ISSUE 6592 471 “off-the-shelf” CAR-T cell ther ...
472 29 APRIL 2022 • VOL 376 ISSUE 6592 science.org SCIENCE PHOTO: MIRCEAX/ISTOCK.COM RESEARCH | IN SCIENCE JOURNALS have a diffe ...
of function in the mouse brain. Selective deletion of TDP-43 from oligodendrocyte precursor cells resulted in their rapid death. ...
473-B 29 APRIL 2022 • VOL 376 ISSUE 6592 science.org SCIENCE RESEARCH PAIN Trk’ing mutations for pain relief The nerve growth fa ...
SCIENCE science.org 29 APRIL 2022 • VOL 376 ISSUE 6592 473-C RESEARCH catastrophic marine extinctions. —SNV Science, abe9039, th ...
RESEARCH ARTICLE SUMMARY ◥ CANCER Stepwise-edited, human melanoma models reveal mutationsÕeffect on tumor and microenvironment E ...
RESEARCH ARTICLE ◥ CANCER Stepwise-edited, human melanoma models reveal mutationsÕeffect on tumor and microenvironment Eran Hodi ...
and technical complexity (Fig. 1B), by sequen- tially introducing mutations into the RB pathway, then the MAPK pathway, and then ...
trajectory in human melanoma may be B→ T→C( 18 , 27 ), we opted to engineer the path C→B→Ttodeferthemoredifficult,precise genome ...
genotypes and, in some cases, help explain the overall cellular phenotypes. Mutation combinations confer distinct, disease-relev ...
occasionally became apparent at the injection site before tissue harvest [7 of 12 injections; Fig. 3D, (n=8), inset: slight upti ...
macular (flat) growths by day 10 that advanced to slow-growing, darkly pigmented tumors by day 29 (Fig. 3C). Finally, CBTP melan ...
Hodiset al.,Science 376 , eabi8175 (2022) 29 April 2022 7 of 14 Fig. 4. Genome-edited melanocytic tumors share expression progra ...
MITF[also associated withTRPM1,CCND1, TYRP1,MLANA, andCDH1(E-cadherin)] were mostly used by tumors with Wnt pathway ac- tivation ...
Hodiset al.,Science 376 , eabi8175 (2022) 29 April 2022 9 of 14 A C G B CAF, contractile CAF, immunom. M1 macrophage M1 and M2 m ...
during macrophage polarization toward the M2 phenotype ( 56 , 57 ); (ii) an“S100/Inter- feron”program, enriched in genes related ...
to phenotypes is highlighted by our observa- tion of how the effect of a given single muta- tion depends on genetic context. For ...
Future studies may explore the effect on ther- apeutic response of the complex genetic inter- actions apparent in these melanoma ...
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