Science - USA (2022-04-29)
was performed on nontraining patches and on melanoma patient samples from The Cancer Genome Atlas (TCGA), processed with the sam ...
clinical behaviour, and phenotypic associations of resistance mechanisms.Eur. J. Cancer 51 , 2792–2799 (2015). doi:10.1016/j.ejc ...
RESEARCH ARTICLE SUMMARY ◥ DOG GENOMICS Ancestry-inclusive dog genomics challenges popular breed stereotypes Kathleen Morrill, J ...
RESEARCH ARTICLE ◥ DOG GENOMICS Ancestry-inclusive dog genomics challenges popular breed stereotypes Kathleen Morrill1,2,3, Jess ...
analysis ( 22 ), defined eight factors that ex- plain a cumulative 24.3% of variance in be- havior (fig. S4 and tables S3 and S4 ...
range 30× to 67×) 27 pet dogs of unknown breed ancestry (the“Mendel’s Mutts”cohort), including 26 from the United States (one or ...
We selected dogs for sequencing on the basis of the enrollment date and survey completion rate (7.4% of dogs had sequencing fund ...
dogs described as registered purebred by own- ers fell above this threshold (Fig. 3F). We designated three classifications of br ...
(fig.S13C).Mostquestions(72%)andfac- tors (63%) are correlated with age [false dis- covery rate (FDR)pvalue (pFDR) < 0.05] (f ...
phrase (e.g., border collies are“affectionate, smart, energetic”and beagles are“friendly, curious, merry”)( 52 ) (table S2). Bre ...
Morrillet al.,Science 376 , eabk0639 (2022) 29 April 2022 8 of 15 not toy− directed not toy−not toy− independent less sociable t ...
Genome-wide association studies in all dogs We first investigated breed-defining physical traits with known large-effect loci us ...
trait) were enriched for SNPs associated in any of the 119 behavioral GWASs (fig. S31). Only one GWAS (Q66,“lifts leg to urinate ...
53.0 ± 30.2% (±SD) of heritability is attribut- able to associated SNPs (p<1×10−^6 ), but for the eight behavioral factors an ...
questions from published and validated sur- veys: (i) Dog Personality Questionnaire (DPQ/ DPQL; 45 questions) ( 37 ); (ii) Canin ...
event that occurred, on average, once every Morgan. Simulations ran on 10 independently drawn datasets of six dogs per reference ...
Genetic differentiation of breeds We calculated genome-wide normalized PBS scores using the Hudson estimator of fixation (FST) f ...
J. A. Kernset al., Linkage and segregation analysis of black and brindle coat color in domestic dogs.Genetics 176 , 1679 – 1689 ...
Publishyourresearch intheSciencefamilyofjournals TheSciencefamilyofjournals(Science, Science Advances,ScienceImmunology, Science ...
RESEARCH ARTICLES ◥ CANCER Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress Brian D ...
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