Innovations_in_Molecular_Mechanisms_and_Tissue_Engineering_(Stem_Cell_Biology_and_Regenerative_Medicine)
75 Rhee DK, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V, Jay GD, Stewart M, Wang H, Warman ML, Carpten JD (2005) The secr ...
76 Cole BJ, DeBerardino T, Brewster R, Farr J, Levine DW, Nissen C, Roaf P, Zaslav K (2012) Outcomes of autologous chondrocyte ...
77 Zhou G, Liu W, Cui L, Wang X, Liu T, Cao Y (2006) Repair of porcine articular osteochon- dral defects in non-weightbearing a ...
78 Pendleton C, Li Q, Chesler DA, Yuan K, Guerrero-Cazares H, Quinones-Hinojosa A (2013) Mesenchymal stem cells derived from ad ...
© Springer International Publishing Switzerland 2016 79 J. Wilson-Rawls, K. Kusumi (eds.), Innovations in Molecular Mechanisms a ...
80 children, however a similar response has been documented in adults [ 4 ]. While human fi ngertip regeneration is well documen ...
81 Days Post-Amputation A E I JK LM FGH BCD Length (mm) ca^00 50 100 150 200 250 (^51015) Days post amputation Percent bone volu ...
82 the casting off of the distal bone fragment. Sequential micro-computed tomography (μCT) 3-D renderings illustrate the intense ...
83 formed the neonatal blastema is similar to the adult blastema, composed of undifferentiated mesenchymal cells with a relative ...
84 tip regeneration , treatment of amputated wildtype digits with Noggin, a BMP signaling antagonist, was found to inhibit the r ...
85 response to BMP2 was the elongation of the P2 skeletal element to almost 90 % of stage-matched unamputated control length, ho ...
86 organization of distally-located proliferating chondrocytes differentiating into hyper- trophic chondrocytes demonstrates the ...
87 Fig. 5.3 ( a ) P2 amputation ( dashed line ) transects the mid-portion of the bone and completely removes the nail organ. ( b ...
88 the bone stump, not distal to the amputation plane. The cartilaginous callus functions as a template for the invading osteobl ...
89 epidermis, (2) endothelial cells contribute only to the vasculature of the regenerate, (3) osteoblasts precursors of the limb ...
90 treatment of human microvascular endothelial cells (HMVEC) stimulated a dose- dependent increase in Sdf-1 transcripts, and th ...
91 blastema cell recruitment during regeneration. In addition, endothelial cells in the blastema and at non-regenerating amputat ...
92 5.5 Wound to Blastema One of the prominent characteristics of the blastema is its relative avascularity compared to surroundi ...
93 functions during the early stages of regeneration to repress VEGF induced re- vascularization and to maintain the blastema in ...
94 In general, tissue vascularity plays a critical role in maintaining physiological function and homeostasis. Although there ar ...
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