Innovations_in_Molecular_Mechanisms_and_Tissue_Engineering_(Stem_Cell_Biology_and_Regenerative_Medicine)
Stem Cell Biology and Regenerative Medicine Jeanne Wilson-Rawls Kenro Kusumi Editors Innovations in Molecular Mechanisms and Tis ...
Stem Cell Biology and Regenerative Medicine Series Editor Kursad Turksen, Ph.D.
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Jeanne Wilson-Rawls • Kenro Kusumi Editors Innovations in Molecular Mechanisms and Tissue Engineering http://www.ebook3000.com ...
ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-44994-4 ISBN 978-3-319-449 ...
v Pref ace Interest in regeneration has waxed and waned since Lazzaro Spallanzani fi rst described salamander limb regeneration ...
vi Judd and Huang provide a comprehensive discussion of cardiomyocyte regenera- tion in multiple model systems, including neonat ...
vii Contents 1 Research into the Cellular and Molecular Mechanisms of Regeneration in Salamanders: Then and Now ................ ...
ix Contributors Caroline P. Addington School of Biological and Health Systems Engineering , Arizona State University , Tempe , A ...
x Paulina Ketcham Department of Veterinary Physiology & Pharmacology , Texas A&M University , College Station , TX , USA ...
© Springer International Publishing Switzerland 2016 1 J. Wilson-Rawls, K. Kusumi (eds.), Innovations in Molecular Mechanisms an ...
2 regenerative potential in salamanders, in comparison to mammals is poorly understood. Classically it has been hypothesized tha ...
3 cord, brain, and lens) were reported less frequently compared to the limb. Adult salamander limb regeneration is a unique prop ...
4 essential tissues for regeneration. The clearest example for the requirement of wound epithelium came from experiments demonst ...
5 this requirement by inducing supernumary tissues to form by rotating tissues of a stump following amputation or rotating a bla ...
6 gland cells of the wound epithelium. Over- expression of this protein is suffi cient to stimulate blastema cell outgrowth of d ...
7 1.3.3 Mechanisms of Outgrowth During Regeneration Found to be Tissue Specifi c A key concept of regenerative medicine is that ...
8 [ 106 , 107 , 109 , 158 ]. Similar mechanisms have been observed in the case of the regenerating telencephalon and dopaminergi ...
9 1.4 Entering the era of Next Generation Sequencing and Genome Editing 1.4.1 Unraveling the Salamander Genome and High- Through ...
10 1.4.2 Genome Editing Technologies Innovations over the last decade in the fi eld of molecular biology have provided a multitu ...
11 loxP and Cre-driver lines that can be bred together and supplemented with tamoxifen to induce Cre-mediated recombination [ 51 ...
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