Science - USA (2019-01-18)
243-B 18 JANUARY 2019 • VOL 363 ISSUE 6424 sciencemag.org SCIENCE RESEARCH ORGANIC CHEMISTRY Synthetic innovation in drug develo ...
SCIENCE sciencemag.org 18 JANUARY 2019 • VOL 363 ISSUE 6424 243-C CELL DIFFERENTIATION Reversing chromatin dynamics for developm ...
REVIEW SUMMARY ◥ ORGANIC CHEMISTRY The importance of synthetic chemistry in the pharmaceutical industry Kevin R. Campos, Paul J. ...
REVIEW ◥ ORGANIC CHEMISTRY The importance of synthetic chemistry in the pharmaceutical industry Kevin R. Campos^1 , Paul J. Cole ...
of peptide-based inhibitors and subsequent molecular modeling suggested that construc- tion of large, macrocyclic enzyme inhibit ...
with both catalysts present. For example, the combination of single-electron transfer–based decarboxylation with nickel-activate ...
application of decarboxylative alkylation chem- istry to the C terminus of a protein substrate ( 48 ) offer new insights into ac ...
that can cyclize peptides with two cysteine resi- dues ( 51 ). Through combined application of a ribozyme biocatalyst to enable ...
conditions that work for these complex substrates. Additionally, HTE has recently been leveraged to benchmark emerging methods a ...
Recently, we conducted a summit with key opinion leaders to assess the state of field and to identify areas of research in synth ...
M. D. Altmanet al., Cyclic Di-Nucleotide Compounds as STING Agonists, WO2017/027646A1 (2017). F. H. Arnold, Directed Evolution: ...
RESEARCH ARTICLE SUMMARY ◥ IMAGING TECHNIQUES Cortical column and whole-brain imaging with molecular contrast and nanoscale reso ...
RESEARCH ARTICLE ◥ IMAGING TECHNIQUES Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution R ...
the N,N-dimethylacrylamide-gel expansion pro- tocol, we observed regions where the expansion superficially appears accurate (fig ...
objective scan because information in the sam- ple scanning direction is slightly blurred by simultaneous image acquisition and ...
Gaoet al.,Science 363 , eaau8302 (2019) 18 January 2019 4of16 Fig. 2. Nanoscale, protein-specific 3D imaging of subcellular neur ...
Gaoet al.,Science 363 , eaau8302 (2019) 18 January 2019 5of16 Fig. 3. Characterizing dendritic spine morphologies and postsynapt ...
influence the speed and efficiency of signal propagation. We subsequently confirmed these observations with EM (fig. S11 and sup ...
even at its dendritic spines (Fig. 3D, neuron 2). This difference did not result from differential labeling efficiency because t ...
longitudinal variation. The repeated gaps in myelination at the nodes of Ranvier house ion channels that are essential to regene ...
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