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Article Extended Data Fig. 11 | See next page for caption. ...
Extended Data Fig. 11 | DNA-PK interacts with structured RNAs that can activate its kinase. a, b, Correlation analysis of total ...
1 nature research | reporting summary April 2018 Corresponding author(s): Shan Zha and Eliezer Calo Reporting Summary Nature Res ...
2 nature research | reporting summary April 2018 Data Policy information about availability of data All manuscripts must include ...
3 nature research | reporting summary April 2018 CD8a(cat. 100704, clone 5.3-6.7, lot. B257790), biotin anti-mouse CD3e(cat. 100 ...
4 nature research | reporting summary April 2018 Flow Cytometry Plots Confirm that: The axis labels state the marker and fluoroc ...
Nature | Vol 579 | 12 March 2020 | 297 Article Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc De ...
298 | Nature | Vol 579 | 12 March 2020 Article highlights the importance of the membrane environment in these processes. Structu ...
Nature | Vol 579 | 12 March 2020 | 299 Data Fig. 1d), which suggests that βarr1 interacts with the 7TM core of M2Rpp only in a l ...
300 | Nature | Vol 579 | 12 March 2020 Article and G protein^14. In M2R–Go, opening of the cytoplasmic portion of TM6 accommodat ...
Nature | Vol 579 | 12 March 2020 | 301 structure shows a large twist in the orientation of the finger loop, due to the N-termina ...
302 | Nature | Vol 579 | 12 March 2020 Article induces conformational changes in β-arrestin, which subsequently promotes its cou ...
Methods No statistical methods were used to predetermine sample size. The experiments were not randomizedand the investigators w ...
Article Statistics were conducted by comparing the area under the curves (GraphPad Prism) from at least three independent experi ...
heated from 0 K to 300 K in 20-K increments with 0.4 ns of simulation at each increment. During the heating phase, harmonic rest ...
Article Extended Data Fig. 1 | Characterization of the M2R–βarr1 complex. a, Schematic showing sortase-mediated ligation of GGG- ...
Extended Data Fig. 2 | M2Rpp-βarr1 complex conformers and cryo-EM reconstruction workf low. a, Conformational variability of the ...
Article Extended Data Fig. 3 | Map resolution and model validation. a, ‘Gold standard’ FSC plots of the reconstruction of M2Rpp– ...
Extended Data Fig. 4 | Structural comparisons of arrestins. a, The tilt of β-arrestin relative to the M2Rpp was measured by the ...
Article Extended Data Fig. 5 | See next page for caption. ...
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