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Article Competing interests Z.L. and M.V.B. have patent applications on epigenetic therapy. J.R.B., C.M.R., P.M.F. and R.A.J. se ...
Extended Data Fig. 1 | Eff icacy of low-dose AET on cancer recurrence in patients with stage I (T1-2aN0) NSCLC in a phase-II cli ...
Article Extended Data Fig. 2 | Schema outlining the establishment and characteristics of the mouse models of pulmonary metastasi ...
Extended Data Fig. 3 | CD11b+GR1+ cells persist as the predominant immune cells even after resection in the lung premetastatic m ...
Article Extended Data Fig. 4 | Consideration of combined AET dosing on the basis of its effect on mouse models. a, Top, effect o ...
Extended Data Fig. 5 | Low-dose AET disrupts the lung premetastatic microenvironment, mainly by affecting MDSCs. a, The effect o ...
Article Extended Data Fig. 6 | Low-dose AET induces substantial changes in immune-cell chemotaxis and migration in MDSCs in LLC ...
Extended Data Fig. 7 | Low-dose AET promotes the differentiation of monocytic MDSCs towards macrophages in the LLC model. a, DAV ...
Article Extended Data Fig. 8 | Low-dose AET promotes the differentiation of monocytic MDSCs towards an interstitial macrophage-l ...
Extended Data Fig. 9 | Low-dose AET inhibits pulmonary metastases and prolongs overall survival in mouse models. a, Representati ...
Article Extended Data Fig. 10 | Representation of the effect of low-dose adjuvant epigenetic modif iers on lung metastases in th ...
1 nature research | reporting summary October 2018 Corresponding author(s): Malcolm V. Brock, Lin Shen, Stephen B. Baylin, Franc ...
2 nature research | reporting summary October 2018 Field-specific reporting Please select the one below that is the best fit for ...
3 nature research | reporting summary October 2018 Validation All antibodies are commercially available and validated by the man ...
4 nature research | reporting summary October 2018 Outcomes Primary Outcome Measures : Disease-free Survival (DFS) [ Time Frame ...
Nature | Vol 579 | 12 March 2020 | 291 Article DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis Zhengpin ...
292 | Nature | Vol 579 | 12 March 2020 Article megakaryocytes, and occasionally c-KIT-positive myeloid blasts (Fig. 1d, Extended ...
Nature | Vol 579 | 12 March 2020 | 293 TP53-dependent macrocytic anaemia with increased mean corpus- cular volume (MCV, RBC size ...
294 | Nature | Vol 579 | 12 March 2020 Article accumulated in CD34− bone marrow cells from patients with DBA^34. Thus, the KU-me ...
Nature | Vol 579 | 12 March 2020 | 295 demonstrated how an endogenous RNA in mammalian cells drives the assembly and activation ...
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