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Extended Data Fig. 5 | Computational and experimental examination of interactions between the f inger loop and M2Rpp. a, Depicti ...
Article Extended Data Fig. 6 | Finger loop rearrangements and ICL2. a, Detail of crystal structure of activated βarr1with phosph ...
Extended Data Fig. 7 | Conservation of lipid-binding regions in the arrestin family. a, Ribbon model of the M2Rpp–βarr1 complex ...
Article Extended Data Fig. 8 | Effects of the lipid membrane on βarr1 coupling to M2Rpp. a, Atomistic simulations of the M 2 Rpp ...
Extended Data Fig. 9 | See next page for caption. ...
Article Extended Data Fig. 9 | βarr1 C-edge–lipid interaction facilitates M2R internalization. a, Flow cytometry analysis of βar ...
Extended Data Table 1 | Cryo-EM data collection, refinement, and validation statistics M2R-arr1- Fab30(scFv) (EMDB-20612) (PDB 6 ...
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Nature | Vol 579 | 12 March 2020 | 303 Article Structure of the neurotensin receptor 1 in complex with β-arrestin 1 Weijiao Huan ...
304 | Nature | Vol 579 | 12 March 2020 Article an intermediate along the activation pathway^9. Recent studies have shown that an ...
Nature | Vol 579 | 12 March 2020 | 305 are known to interact with phosphorylated receptor residues^28. The receptor core engages ...
306 | Nature | Vol 579 | 12 March 2020 Article (Fig. 3a). Third, we observe that the polar core is disrupted, as evidenced by th ...
Nature | Vol 579 | 12 March 2020 | 307 R236Q /K250Q)—containing lysine-to-glutamine substitutions at resi- dues 232 and 250, and ...
308 | Nature | Vol 579 | 12 March 2020 Article between NTSR1–βarr1(ΔCT), M2R–βarr1 and Rho–Arr1, suggesting that this loop can b ...
Methods Data analysis and figure preparation Figures were created using the PyMOL 2.3.2 Molecular Graphics Sys- tem (Schrödinger ...
Article column (GE Healthcare). The column was washed with 1 column volume (CV) of a linear gradient from 0 to 10% buffer B (20 ...
Thermomixer, without agitation, for one hour. After digestion peptides were sequentially eluted by spinning through 40 μl of 50 ...
Article 10% fetal bovine serum (Gibco), glutamine, penicillin and streptomy- cin) 1 day before transfection. Transfection soluti ...
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