Nature - USA (2019-07-18)
Letter reSeArCH b 0 1 -1 1.5 Relative mRNA expression,RNA-seq (Log ) 2 Wnt3 0.5 -0.5 Egf NotumBst1 expressed genes142 differenti ...
reSeArCH Letter h j c i 0.5 1.0 1.5 Lgr5 hi : Paneth DMSO IWP-2 100nMIWP-2 500nM 0.0023 0.047 DMSO IWP-2 500nM DMSO IWP-2 500nM ...
Letter reSeArCH d pS6 actin Young Old pS6K 0 1 2 3 Relative pS 6 0.0013 YO 0 1 Relative pS6K 2 0.13 YO pS6lo pS6hi % of pS6hi Ol ...
reSeArCH Letter h a b i Rapamycin Control YoungOld fe c g k m pS6 H3 Tsc1 S6 Tsc1WT Sorted Epcam+ cells pS6 actin YV YR OV OR YV ...
Letter reSeArCH c 0.5 1.0 1.5 2.0 Lgr5 hi : Paneth DMSO GW6471 CHIR99021 0.0090 0.019 0.42 DMSOGW6471 5uMGW6471 5uM + Wnt3A 100n ...
reSeArCH Letter a Control Notum KO 2 gRNA 2 site Exon 3 294 bp 188 bp Exon 123456789101112 gRNA 1 sequenceSignal gRNA 2 300 200 ...
Letter reSeArCH a b d 1 2 3 4 Nuclear b-Catenin MFI relative to TA-cell ABC99: -+ - + YYOO Paneth cells 57n= 77 0.930.230.63 TA ...
reSeArCH Letter 0 1234567 0.80 0.85 0.90 0.95 1.00 0123456701234567 0 1234567 0.80 0.85 0.90 0.95 1.00 0123456701234567 Relative ...
1 nature research | reporting summary October 2018 Corresponding author(s): Pekka Katajisto Last updated by author(s):Apr 25, 20 ...
2 nature research | reporting summary October 2018 Data Policy information about availability of data All manuscripts must inclu ...
3 nature research | reporting summary October 2018 Lysozyme, DAKO, EC3.2.1.17, 1:750 (immunofluorescence) and 1:500 (cytochemist ...
4 nature research | reporting summary October 2018 disease, bleeding disorder that would preclude biopsy, active infection, or s ...
Letter https://doi.org/10.1038/s41586-019-1311-3 Distinct modes of mitochondrial metabolism uncouple T cell differentiation and ...
reSeArCH Letter TCA cycle supports TH1 function by enabling cytosolic acetyl-CoA production and by fuelling a succinate-dehydrog ...
Letter reSeArCH are processes that are uncoupled by complex II activity (Fig. 2c). To test whether processes in addition to prol ...
reSeArCH Letter defects (Fig. 3c, d). By contrast, H3K27 acetylation was largely unaf- fected by targeting these genes (with the ...
Letter reSeArCH cell cycle and adopt their terminal program (Extended Data Fig. 10). These findings illustrate how differentiati ...
reSeArCH Letter Methods T cell assays and sgRNA delivery. CD4 T cells were isolated from constitutive Cas9-expressing (Cas9tg) B ...
Letter reSeArCH Extended Data Fig. 1 | Acute ETC inhibition alters cell cycle, but not viability, in TH1 cells. a, Viability mea ...
reSeArCH Letter Extended Data Fig. 2 | ETC regulation of proliferation is conserved among subtypes of T helper cells, but ETC re ...
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