Nature - USA (2019-07-18)
3 nature research | reporting summary April 2018 Antibodies Antibodies used AR (1:1,000, N-20, Santa Cruz), FOXA1 (1:1000, Ab2, ...
4 nature research | reporting summary April 2018 Peak calling parameters Specify the command line program and parameters used fo ...
Letter https://doi.org/10.1038/s41586-019-1347-4 Distinct structural classes of activating FOXA1 alterations in advanced prostat ...
reSeArCH Letter WNT signalling pathways (Extended Data Fig. 2i, k), and had higher levels of expression of FOXA1 mRNA relative t ...
Letter reSeArCH from patients revealed the activation of hyperproliferative and pro- tumorigenesis pathways, and further enrichm ...
reSeArCH Letter the top regulatory transcription factors for the upregulated genes (Extended Data Fig. 7g, h). The LEF–TCF compl ...
Letter reSeArCH and TTC6—but not of MIPOL1, which has its promoter outside of the FOXA1 topologically associating domain (Extend ...
reSeArCH Letter FOXMIND to drive overexpression of FOXA1 or other oncogenes (Fig. 4e). In summary, we identify three structural ...
Letter reSeArCH METHODS Cell culture. Most cell lines were originally purchased from the American Type Culture Collection (ATCC) ...
reSeArCH Letter selection for 48 h, after which a fraction of these cells was processed to isolated genomic DNA as the input sam ...
Letter reSeArCH 250 rpm until an optical density at 600 nm (OD 600 ) of 0.4–0.5 was reached. The starter brother was then used ...
reSeArCH Letter cat. no. FC-121-1031). Samples were immediately purified by Qiagen minElute column and PCR-amplified with the NE ...
Letter reSeArCH Genetic characterization of mCRPC tumour samples at the pathway level. The co-occurrence or mutual exclusivity o ...
reSeArCH Letter translocations preserve the FOXMIND-FOXA1 regulatory domain but insert the translocation partner upstream of the ...
Letter reSeArCH Extended Data Fig. 1 | See next page for caption. ...
reSeArCH Letter Extended Data Fig. 1 | Functional essentiality and recurrent alterations of FOXA1 in AR+ prostate cancer. a–c, A ...
Letter reSeArCH Extended Data Fig. 2 | See next page for caption. ...
reSeArCH Letter Extended Data Fig. 2 | Genomic characteristics of the three classes of FOXA1 alterations in prostate and breast ...
Letter reSeArCH 7.5mins 10mins Pre 0mins 2.5mins 5.0mins FOXA1-P375fs 7.5mins 10mins Pre 0mins 2.5mins 5.0mins FOXA1-A287fs C-te ...
reSeArCH Letter Extended Data Fig. 3 | Biophysical and cistromic characteristics of the class-1 FOXA1 mutants. a, Distribution o ...
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