Nature - USA (2020-10-15)

Up in 25C plate vs liquid Up in 25C plate vs 15C plate Up in 25C plate vs both 25C upregulated PA14 small RNAs b ErsA P2^4 Sr3^2 ...

Article -1.0 -0.8 -0.6 -0.4 -0.2 0.0 0.2 0.4 0.6 0.8 1.0 P11 choice assay Choice Index n.s. 24 h OP50 trained 24 h PA14 trained ...

P11 17nt match -0.6 -0.4 -0.2 0.0 0.2 0.4 0.6 0.8 1.0 Choice Inde x P0 vhp-1(sa366) **** **** n.s. N2 vhp-1(sa366) -0.8 -0.6 -0. ...

Article Extended Data Fig. 7 | P11 region of homology with mac o -1 and behaviour of vhp -1 mutants. a, Wormbase depiction of th ...

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452 | Nature | Vol 586 | 15 October 2020 Article Structural basis for dimerization quality control Elijah L. Mena1,6, Predrag Je ...

Nature | Vol 586 | 15 October 2020 | 453 map independently obtained by cryo-EM (Fig. 1c). As expected, FBXL 17 uses its F-box to ...

454 | Nature | Vol 586 | 15 October 2020 Article caught by FBXL17, the amino-terminal β-strand folds back onto its own C-termina ...

Nature | Vol 586 | 15 October 2020 | 455 KEAP1 a F139 I145S144 A143 Y54 L56 F64 A17^0 KEAP1mutant KEAP1 KEAP1 MBP–FBXL17 Coomass ...

456 | Nature | Vol 586 | 15 October 2020 Article as leucine zippers or zinc fingers, which mediate specific dimerization events. ...

Methods Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized. The in ...

Article Mass spectrometry We used multidimensional protein identification technology (MudPIT) to analyse mass spectrometry sampl ...

The initial SKP1–FBXL17–KEAP1BTB complex model was improved using Phenix Rosetta Refine^34. The software used was curated by SBG ...

Article 2AST) structures were used for comparison with that of SKP1–FBXL17. Similarly, a KEAP1 homodimer was aligned to the SKP1 ...

of KEAP1(F64A), KEAP1(S172A/F64A/R116C) was first exchanged into filtered, degassed DPBS using SEC and subsequently concentrated ...

Article Extended Data Fig. 1 | Variant BTB domains of KEAP1 are recognized by SCFFBXL17. a, Mutations in KEAP1’s BTB domain resu ...

Extended Data Fig. 2 | Cryo-EM data collection and processing. a, Representative micrograph (graphene oxide coated grid, imaged ...

Article Extended Data Fig. 3 | SCFFBXL17 binds the BTB domain, but its active site is next to the Kelch repeats of KEAP1. a, Elu ...

Extended Data Fig. 4 | See next page for caption. ...