Nature - USA (2020-09-24)
Extended Data Fig. 7 | AGPAT3 contributes to PUFA-ePL synthesis downstream of peroxisomes. a, Immunoblot analysis of ACSL4 and L ...
Article b 48hrs pre-treat 72hrs ML210 Viability cancer cells Phospholipid nanoparticles P O-O O O NH 3 + O O O O NP1: C18:0-20:4 ...
Extended Data Fig. 8 | Polyunsaturated ether lipid nanoparticles increase cellular sensitivity to ferroptosis. a, Schematic of t ...
Article c d 050 100 150 0 20 40 60 Relative gain in ox-BODIPY -C1 1 signal 050 100 150050 100 150 050 100 150 Vehicle C18 (plasm ...
sgNC AGPS-sg1 FAR1-sg2 PEX3-sg1 AGPAT3-sg1 786-O xenograft tumors 0714 21 28 35 42 0 200 400 600 800 786-O xenograft Dayspost in ...
Article Extended Data Fig. 10 | PUFA-ePL downregulation is associated with acquired ferroptosis resistance in vivo. a, Immunoblo ...
-2 -1 01 0.00 0.25 0.50 0.75 1.00 1.25 Log 10 ( M ML210) -3 -2 -1 0 Log 10 ( M RSL3) sgNC TMEM189-sg 1 TMEM189-sg 2 TMEM189-sg 3 ...
Article . c 0.0 0.4 0.8 1.2 Relative mRNA level PEX3 AGPS si-NC si-PEX3 si-AGPS Cardiomyocytes (CM) Cardiac progenitor s (CP) Nu ...
Extended Data Fig. 12 | Neurons and cardiomyocytes acquire increased ether-phospholipid levels and elevated sensitivity to ferro ...
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Nature | Vol 585 | 24 September 2020 | 609 Article Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin Silvija Bilok ...
610 | Nature | Vol 585 | 24 September 2020 Article αE of the PARP2 catalytic HD subdomain interacts with the linker DNA of the s ...
Nature | Vol 585 | 24 September 2020 | 611 abolished DNA-dependent H3 PARylation, consistent with a role of V141 in transmitting ...
612 | Nature | Vol 585 | 24 September 2020 Article are flexible (Fig. 3a, b, Extended Data Fig. 8a–c). This is consistent with d ...
Nature | Vol 585 | 24 September 2020 | 613 factors involved in DNA repair. Subsequently, the reaction slowly switches from histo ...
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