Nature - USA (2020-09-24)

Article Author contributions G.N., C.D.M. and A.B. conceived the study. G.N., C.D.M. and A.E. designed the experiments. G.N. and ...

Extended Data Fig. 1 | TFEB phosphorylation is insensitive to serum starvation. a, HeLa cells stably expressing GFP–TFEB were st ...

Article Extended Data Fig. 2 | TFEB phosphorylation is insensitive to the R H E B –T S C a x i s. a–c, HeLa (a), HEK293T (b) or ...

Extended Data Fig. 3 | Rag GTPases are required for TFEB phosphorylation. a, HeLa cells stably expressing GFP–TFEB were transfec ...

Article Extended Data Fig. 4 | Rag GTPases are required for TFEB phosphorylation regardless of mTORC1 activation status. a, b, G ...

Extended Data Fig. 5 | The mTORC1 substrate-recruitment mechanism of TFEB is determined by its N-terminal region. HeLa cells wer ...

Article Extended Data Fig. 6 | See next page for caption. ...

Extended Data Fig. 6 | Addition of a TOS motif to a Rag-binding-def icient TFEB mutant rescues its phosphorylation and subcellul ...

Article Extended Data Fig. 7 | Activation of RagA is essential for mTOR lysosomal recruitment and TFEB cytosolic localization. a ...

Extended Data Fig. 8 | TFEB phosphorylation and cytosolic retention requires active RagC/D. a, RagC-knockout HeLa cells were tra ...

Article Extended Data Fig. 9 | Genomic and mRNA analysis of transgenic mouse lines. a, PCR analysis of genotypes from kidney sam ...

Extended Data Fig. 10 | See next page for caption. ...

Article Extended Data Fig. 10 | TFEB is constitutively nuclear and active in FLCN- knockout kidneys, and its depletion rescues m ...

1 nature research | reporting summary October 2018 Corresponding author(s): Andrea Ballabio Last updated by author(s):Apr 16, 20 ...

2 nature research | reporting summary October 2018 For a reference copy of the document with all sections, see nature.com/docume ...

3 nature research | reporting summary October 2018 Rheb1: https://www.cellsignal.com/products/primary-antibodies/rheb-e1g1r-rab ...

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