Medicinal Chemistry

imidazoles) and six-membered (pyrimidines, pyridines) heterocycles have been explored as potential structural cores. These vario ...

The gonadotropins are released in a pulsed manner. Lutropin and follitropin act together to regulate ovarian functions, egg matu ...

The primary effect of ACTH seems to be mediated via cAMP production by interaction of the hormone with differing populations of ...

oxytocin/antidiuretic activity ratio of 135,000:1, compared to the 200:1 ratio of the natural hormone. On the other hand, the [1 ...

Diabetes insipidus is treated with highly active synthetic vasopressin analogs. Desmopressin acetate (5.79, DDAVP) is synthetic ...

poppy”)—have been used since ancient Chinese and classical Greek times to modify pain perception, but also misused for their eup ...

brain. Since the genetic code for methionine (AUG) differs by only one base from one of the leucine codons (CUG), a point mutati ...

All of these receptors are G-protein-coupled receptors with a high degree of amino acid sequence homology amongst them. On pharm ...

Withdrawal symptoms can be immediately precipitated in addicts by the administration of narcotic antagonists. 5.18.6 Biochemical ...

Even though pure morphine has been available since 1803, its structure was finally elucidated only in 1925, by Sir Robert Robins ...

TheN-methyl substituenton morphine is not absolutely essential to its analgesic activity; such activity is instead more a questi ...

5.18.9.2 Benzomorphan and Metazocine Series Opening of the C ring as well as omission of the D ring of morphine results in the 6 ...

Lengthening of the N-substituent in meperidine leads to active analgesics such as the propiophenone analog, which is 200 times m ...

(5.99), is even more useful, since it is longer acting. Levallorphan (5.100) and cyclorphan (5.101) are morphinane derivatives, ...

stimulating hormone, TSH). The latter is a pituitary glycoprotein whose αsubunit is identical with that of lutropin (LH) and who ...

to Lys^9 and Lys^15. The 4'-OH is a requirement for binding, which shows negative cooperativity. It is interesting that, in addi ...

c-erboncogene; other family members include the vitamins A and D receptors and steroid hormone receptors. The T 3 receptor exist ...

uptake by the thyroid gland; but they have severe side effects. In recent years, the drugs of choice for controlling hyperthyroi ...

pre-pro-PTH with an additional 31 amino acids and a pro-PTH with an additional 6 amino acids only. Parathyroid hormone increases ...

the two connecting disulphide bonds can meet properly. Proinsulin is more soluble than insulin, but has only about 35% insulin-l ...