Medicinal Chemistry

Stimulation of DNA translation Increased lipid synthesis Stimulation of Na+,K+, and Pitransport into cells Insulin is therefor ...

subcutaneous point of injection is retarded; these suspensions are achieved by creating poorly water-soluble complexes of the an ...

The biguanides consist of phenformin (5.121), buformin (5.122) and metformin (5.123). Phenformin was discontinued in the USA bec ...

These agents are most widely used in patients with refractory obesity who have ineffective insulin action. The thiazolidinedione ...

frequently in older people and which results from relative insulin deficiency and insulin resistance, frequently arising from ob ...

5.20.2 Glucagon Glucagon, the second pancreatic hormone, was discovered as an impurity in early insulin preparations. It is a pe ...

5.21.1 Characterization of the Renin–Angiotensin System Angiotensinogen (pre-proangiotensin) is produced by the liver; it is a g ...

inhibitor that leads to a significant, short-duration lowering of the blood pressure following intravenous injection. Two partia ...

researchers at Merck sought to replace the sulfhydryl group with a bioisosterically equivalent carboxylate group that could bind ...

enalapril and is a lysine derivative of enalaprilat. Lisinopril and captopril are currently the only two ACE inhibitors in clini ...

angiotensin receptor antagonists are active only during continuous intravenous infusion, and are therefore seldom if ever used. ...

ANP now belongs to a family of natriureteic peptides that also includes BNP (brain natriuretic peptide) and CNP (C-type natriure ...

with a concomitant and dramatic hypotensive effect. Modification of these peptides may lead to the discovery of more active and ...

pressure greater than 96 torr. If the diastolic value exceeds 115 torr, then the afflicted individual has severe hypertension. I ...

Direct vasodilators: reduce pressure by dilating resistance vessels (arteries) by vascular smooth muscle relaxation (e.g., Ca^2 ...

more drugs from the four starter groups listed above with one or more drugs from the following four groups: Central α 2 agonist ...

techniques for searching conformational space (chapter 1). In addition, peptidomimetic chemistry techniques using bioisosteric s ...

D. F. Smith, D. O. Toft (1993). Steroid receptors and their associated proteins. Mol. Endocrinol. 4 :7. Y. Tabata, H. Osada (200 ...

C. Fleck, M. Schwertfeger, P. M. Taylor (2003). Regulation of renal amino acid (AA) transport by hormones, drugs and xenobiotics ...

T. Hedner, X. Sun, I. L. Junggren, A. Pettersson, L. Edvinsson (1992). Peptides as targets for antihypertensive drug development ...