Medicinal Chemistry

9.6.1 Antiparasitic Drugs Targeting Protozoans Although there is a variety of protozoan infestations, malaria is probably the mo ...

Many antimalarial agents have a common structural feature: a quinoline ring or an acridine ring (which is a quinoline ring with ...

9.6.2 Antiparasitic Drugs Targeting Helminths A variety of structurally diverse compounds is used to eradicate or at least reduc ...

Mebendazole (9.120), a synthetic benzimidazole, is a broad-spectrum oral antihelminthic used for ascariasis, pinworm infestation ...

Niclosamide (9.122), a salicylamide derivative, is the drug of choice for most tape- worm infestations. Niclosamide inhibits oxi ...

Thiabendazole (9.126), a benzimidazole, is used to treat strongyloidiasis and trichinosis. Within the parasite, thiabendazole in ...

In some people, the associated failure of breathing can lead to death. The infectious agents that cause pneumonia are many and v ...

antibiotic therapy was left as ceftriaxone and vancomycin. (If the Gram stain had revealed Gram-positive bacilli, then the empir ...

large that it exceeds the ability of an organism to excrete the substance, then the chemical accumulates within the tissues of t ...

valence electrons very strongly; hard cations are not readily polarized and are of small size and high charge. Conversely, a sof ...

restricted to chelating agents for heavy-metal poisoning. However, health effects extend to the numerous organic chemicals in ou ...

A. G. Brown (1985). Clavulanic acid and related compounds: inhibitors of β-lactamase enzymes. In: S. M. Roberts, B. J. Price (Ed ...

D. J. Waxman, J. L. Strominger (1983). Penicillin-binding proteins and the mechanism of action ofβ-lactam antibiotics. Annu. Rev ...

W. A. Petri, U. Singh (1999). Diagnosis and management of amebiasis. Clin. Infect. Dis. 29: 1117. J. E. Rosenblatt (1999). Antip ...

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Appendix: Drugs Arranged by Pharmacological Activity CARDIOLOGY Angina BETA-ADRENERGIC BLOCKING AGENTS, SELECTIVE,INTRINSIC SYMP ...

CLASSIV,CALCIUM CHANNEL BLOCKERS diltiazem hydrochloride verapamil hydrochloride VARIOUS ANTIARRHYTHMICS adenosine CARDIAC SYMPA ...

BETA-ADRENERGIC BLOCKING AGENTS, SELECTIVE,NON-ISA atenolol bisoprolol fumarate esmolol hydrochloride metoprolol tartrate BETA-A ...

ANTIBIOTICS erythromycin erythromycin estolate minocycline hydrochloride tetracycline hydrochloride RETINOIDS isotretinoin Topic ...

methoxsalen psoralens RETINOIDS acitretin Psoriasis therapy, topical ANTRACEN DERIVATIVES anthralin PSORALENS methoxsalen RETINO ...