A Guidebook to Mechanism in Organic Chemistry
Addition to Carbon-Oxygen Double Bonds This acyloin condensation is much used for the ring-closure of long chain dicarboxylic es ...
Addition of Carbanions bromide has, however, been isolated in crystalline form as the com pound C 8 H 8 MgBr-2Et 2 0, in which ...
Addition to Carbon-Oxygen Double Bonds This is, indeed, observed in practice; the ketone is in part reduced to the secondary alc ...
Aldol Reactions (XXX) which can attack the carbonyl carbon atom of a second mole cule of aldehyde to yield, ultimately, the ald ...
Addition to Carbon-Oxygen Double Bonds Aldehydes having no a-hydrogen atoms cannot form carbanions and they therefore, undergo t ...
Aldol Reactions O OH O RCH,-C* rCHv-N O 1 H t Oe CH,=N—Or O R CH,—C—CH.,—N—Oe H H,0 R • CH 4 • CH(OH) • CH 2 • NO, in the adjace ...
Addition to Carbon-Oxygen Double Bonds carbonyl carbon atom, and p-MeO-C 6 H 4 -CHO is found to react at only about one-seventh ...
Claisen Ester Condensation CHgCOjEt Cf &CH,C0 2 Et OEt (XXXVII) + EtOH Me—C O II Me—C—CHCOjEt O II Me—C—CH» • COjEt (XXXIX) ...
Addition to Carbon-Oxygen Double Bonds Crossed condensation of two different esters is not always practi cable because of the f ...
Benzoin Reaction i.e. the so-called 'acid decomposition' of /?-keto esters. An exactly analogous fission of /3-diketones also ta ...
Addition to Carbon-Oxygen Double Bonds support the above formulation and the rate-determining step is be lieved to be the react ...
* Stereochemistry of Addition to Carbonyl Compounds The reactions to form the so-called Mannich bases (XLVII) are be lieved to ...
Addition to Carbon-Oxygen Double Bonds R X R R R' R X R' R X R' \i/ \ / \i/ \i/ C trans C cis C C I ^— II — I <±> c c c o ...
Nucleophilic Attack on Carboxylic Acid Derivatives rule enunciated by Cram which has been found to forecast accur ately the maj ...
Addition to Carbon-Oxygen Double Bonds The reactivity sequence is well illustrated by the fact that acid chlorides react readily ...
Acid Catalysed Reactions does not play any significant part in the amide formation. Both transesterification and amide formation ...
Addition to Carbon-Oxygen Double Bonds (tl) Attack by the nucleophile, ROH, apparently need* to occur from a direction more or l ...
Acid Catalysed Reactions place. It is found however, that if the acid is dissolved in concentrated H 2 S0 4 and the resultant so ...
Addition to Carbon-Oxygen Double Bonds * protonated 2,4,6-trimethylbenzoic acid cannot as the o-methyl groups prevent the atoms ...
ELIMINATION REACTIONS ELIMINATION reactions are those in which two groups are removed from a moWBle without being replaced by ot ...
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