Textbook of Personalized Medicine - Second Edition [2015]

142 association study on lumiracoxib-treated patients with liver injury and matched lumiracoxib-treated patients without liver i ...

143 Tranilast-Induced Hyperbilirubinemia due to Gene Polymorphism PRESTO (Prevention of REStenosis with Tranilast) was a double- ...

14 4 companies are building large electronic databases of clinical and genomic information that the FDA believes can be useful i ...

145 confounding factors. Drug response might be predicted from a certain pattern of polymorphisms rather than only a single poly ...

146 postulated for indirect effects in which acute exposure to a drug infl uences signaling pathways that may lead to an alterat ...

147 References Chen P, Lin JJ, Lu CS, et al. Carbamazepine-induced toxic effects and HLA-B1502 screening in Taiwan. N Engl J Med ...

148 Reynolds KK, Valdes R, Hartung BR, Linder LW. Individualizing warfarin therapy. Pers Med. 2007;4:11–31. SEARCH Collaborative ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_5, 149 © Springer Science+Business Media New York 20 ...

150 these complex multifactorial situations to obtain individual genotypic and gene expression information. These same tools are ...

151 before prescribing in order to determine which drug regimen best fi ts their genetic makeup. Pharmacogenomic studies are rap ...

152 Pharmacogenomics and Drug Discovery The impact of new technologies at various stages of the drug discovery process is shown ...

153 Another important stage in drug discovery is lead selection that can be based equally upon biomarkers of toxicity or biomark ...

154 full development of compounds. The availability of genomic samples in large phase IV trials provides a valuable resource for ...

155 Impact of Genetic Profi ling on Clinical Studies Genotyping is important in design and interpretation of clinical studies. A ...

156 It is anticipated that genotyping at different stages of clinical trials would change the approach to drug development. Curr ...

157 An alternative to prospective controlled clinical trials is simple examination of a treated population in a clinic by retros ...

158 with their doctor. With the right information and support, patients will be able to participate alongside their doctors in m ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_6, 159 © Springer Science+Business Media New York 20 ...

160 The industrial sector is taking a lead in developing this area. Individualized therapy may be based on differential protein ...

161 phagosome proteome. Phagosomes are required by macrophages to participate in tissue remodeling, clear dead cells, and restri ...