Textbook of Personalized Medicine - Second Edition [2015]

40 analysis. It enables detection and localization of mismatched or unmatched nucleotides within heteroduplex DNA. EMD employs n ...

41 context on a person with a family history of vascular disease and early sudden death (Ashley et al. 2010 ). Sequencing was do ...

42 RNA Sequencing With the recognition of importance of RNA metabolism for brain function, as well as malfunction, there is an i ...

43 A publication has demonstrated the value of NGS for genetic risk assessment and evaluated the limitations and barriers for th ...

44 Personal Genome Project Achieving personalized medicine will require extensive research on highly re- identifi able, integrat ...

45 Role of Biochip/Microarray Technology in Personalized Medicine Microarray technology not only helps to make sense of the vast ...

46 severity of the disease and to identify the genes that can be targeted for therapy. This is how microarrays can be used to de ...

47 Biochip Technologies Numerous biochip technologies are available for clinical applications. Some examples that are relevant t ...

48 One solution for increasing the number of different targets that are amplifi ed in a single PCR reaction is the spatial separ ...

49 Arrayit® H25K Arrayit® H25K is the only genome microarray based on the completely sequenced human genome. It contains a fully ...

50 protocol with 100 % success rate. Small initial concentrations of DNA can be amplifi ed and successfully genotyped on the Amp ...

51 Optical Mapping Optical Mapping™ (OpGen Inc) involves the capture of multiple copies of whole genomes, as collections of long ...

52 Biosensor Technologies for Biochips Biosensors incorporate a biological sensing element that converts a change in an immediat ...

53 DNA-Based Biosensors DNA biosensors are being developed as alternatives to conventional DNA microarrays. These devices couple ...

54 Read one or more of the target protein(s) retained by a rapid, sensitive, laser- induced process (SELDI) that provides direc ...

55 specifi c autoantibodies, using arrays of large numbers of recombinant proteins of known identity. Such arrays overcome the p ...

56 For example, different proteins such as antibodies, antigens, and enzymes can be immobilized within protein biochips. Protein ...

57 FISH-on-chip technology has potential clinical applications for cost-effective screening of cancer patients. The rapid detect ...

58 LabCD The LabCD (TECAN) is a consumable compact disc with micro-scale fl uid paths, reaction chambers and valves. Fluid is mo ...

59 The role of SNPs in clinical trials is: Genotyping is important in design and interpretation of clinical studies. Advantages ...