Textbook of Personalized Medicine - Second Edition [2015]

102 drug disposition and pharmacodynamics. Causes of variations in drug metabolism include the following: Individual factors su ...

103 Pharmacogenetics of Phase I Metabolism The most important of these enzymes is the CYP450 group. CYP450 The cytochrome P450 e ...

104 Table 4.2 Examples of mutation of the enzyme CYP450 CYP450 enzyme Prototype substrate Allele Mutation CYP2D6 Debrisoquine 2X ...

105 CYP2C9 Two inherited SNPs termed CYP2C92 (Arg144Cys) and CYP2C93 (Ile359Leu) are known to affect catalytic function. About 3 ...

106 paroxetine, increases in imipramine concentrations with fl uvoxamine, and increased phenytoin concentrations with sertraline ...

107 the loss-of-function CYP 2C192 variant (rs4244285). Findings in the PAPI Study were extended by examining the relation of CY ...

108 The prevalence of G6PD defi ciency differs among ethnic groups. For instance, males of African and Mediterranean descent mor ...

109 hydralazine, whereas the fast acetylator phenotype may not respond to isoniazid and hydralazine in the management of tubercu ...

110 Measurement of CYP Isoforms A number of well characterized CYP substrates and inhibitors have been identifi ed that allow pr ...

111 Polymorphism of Drug Transporters Transporters are involved in the transport of proteins, peptides, amino acids, ions and ce ...

112 Corporation offers a kinase SNP discovery program for customized polymorphism mapping of human kinase genes. Amplicon modeli ...

113 metabolism alleles within a single panel. The DMET Plus biomarker panel contains biomarkers in all FDA-validated genes and c ...

114 Several studies have shown ethnic differences in drug metabolism mediated by CYP2D6 or CYP2C19 have been summarized elsewher ...

115 trials as compared to men. Use of statins in women is associated with a higher rate of complications such as myositis and co ...

116 Adverse Drug Reactions in Children The problem of ADRs in children is being increasingly recognized, and they differ from ad ...

117 Genetically Determined Adverse Drug Reactions One reason for the high incidence of serious and fatal ADRs is that the existi ...

118 Other genetic biomarkers that can be used to predict ADRs are (Ingelman- Sundberg 2008 ): UGT1A1*28 to predict ADRs to irin ...

119 carbon dioxide, muscle rigidity, acidosis, tachycardia, tachypnea, hyperthermia, and evidence of rhabdomyolysis. This proces ...

120 Role of Pharmacogenetics in Warfarin Therapy Warfarin (Coumadin) is the most commonly prescribed oral anticoagulant for the ...

121 A genome-wide association study found gene polymorphisms that affect the anticoagulant effect of warfarin (Takeuchi et al. 2 ...