Textbook of Personalized Medicine - Second Edition [2015]

162 normally, causing them to clump together and form toxic deposits in neurons. The disease can also arise if neurons make too ...

163 acts as a scaffolding or template for folding rather than as a competitive antagonist. These fi ndings present therapeutic o ...

16 4 Role of Reverse-Phase Protein Microarray in Drug Discovery Reverse-phase protein microarray (RPMA) is a technology platform ...

165 the future. Even the most useful disease biomarkers such as prostate-specifi c antigen, are proteins. The pathomechanism-bas ...

166 to peroxisome proliferators. Current limitations involving speed of throughput are being overcome by increasing automation a ...

167 earlier by measuring WST-1 than by measuring LDH release because the reduction of mitochondrial respiration is an expression ...

168 Applications of Pharmacoproteomics in Personalized Medicine Examples of clinical applications of proteomic technologies will ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_7, 169 © Springer Science+Business Media New York 20 ...

170 or relatively rare. Approximately 5,688 protein sequences are linked to these metab- olite entries. Each MetaboCard entry co ...

171 long-chain fatty acid metabolism and attention defi cit hyperactivity syndrome. Understanding these connections, in turn, ma ...

172 networks. The technologies used include NMR, direct infusion mass spectrometry, and/or infrared spectroscopy. Gas chromatogr ...

173 novel ACE (Automated Comparison of Electropherograms) software which not only removes errors due to baseline shifts but also ...

174 chemicals simultaneously. Multivariate metabolomic and proteomic data and time- series measurements can be combined to revea ...

175 that are characteristic of the individual can be used to diagnose diseases, predict an individual’s future illnesses, and th ...

176 platform used to generate profi les is that the analytical variation introduced postcol- lection be less than the typical va ...

177 Gieger C, Geistlinger L, Altmaier E, et al. Genetics meets metabolomics: a genome-wide associa- tion study of metabolite pro ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_8, 179 © Springer Science+Business Media New York 20 ...

180 Circadian Rhythms and Personalized Medicine Various physiological and metabolic processes in the human body including sleep- ...

181 The body needs a completely different set of genetic programs to perform activities than it does for sleep and restoration. ...

182 not necessarily respond to it. Although there is considerable improvement in safety and effi cacy of a limited number of dru ...