Textbook of Personalized Medicine - Second Edition [2015]

80 examination of a minimally invasive blood sample, can provide biomarkers of several different disease states. These profi les ...

81 of thousands that are expressed in cancers to a few hundred or less that show signifi cant disparity under comparative condit ...

82 timing and position of the detection that indicates the position of the molecule in time and space. Images can then be constr ...

83 Companion Diagnostics Regardless of the name, the combination of diagnosis with therapy will have a major impact on the diagn ...

84 An example of drug with recommendation for companion diagnosis in label information that lists genetic susceptibility relatin ...

85 will facilitate development of POC tests. Nanotechnology- based diagnostics provides the means to monitor drugs administered ...

86 Inadequate discussion or patient counseling Reduced opportunity for internal and external quality assurance, with associated ...

87 Preventive Genetics by Early Diagnosis of Mitochondrial Diseases Diseases resulting from mutations in mitochondrial DNA are c ...

88 current research awards for future projects are to validate and refi ne established technologies including those to detect ge ...

89 Jain KK. DNA sequencing. Basel: Jain PharmaBiotech Publications; 2015b. Jain KK. Molecular diagnostics. Basel: Jain PharmaBio ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_3, 91 © Springer Science+Business Media New York 201 ...

92 A pharmacogenomic test is an assay intended to study interindividual variations in whole-genome or candidate gene, SNPs, hapl ...

93 Role of Biomarkers in Development of Personalized Drugs In addition to personalizing the use of existing drugs, the developme ...

94 Biomarkers for Monitoring Response to Therapy One of the important aspects of personalized medicine is the ability to monitor ...

95 Bioinformatics to Sort Biomarker Data for Personalized Medicine Bioinformatics methods are being applied for the development ...

96 component of any clinical trial. Unlike frequentist methods, Bayesian methods assign anything unknown a probability using inf ...

97 References Berry DA. A guide to drug discovery: Bayesian clinical trials. Nat Rev Drug Discov. 2006;5:27–36. Jain KK. The han ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_4, 99 © Springer Science+Business Media New York 201 ...

100 Role of Molecular Diagnostics in Pharmacogenetics Molecular diagnostic technologies used for pharmacogenetics have been desc ...

101 Genotyping involves identifi cation of defi ned genetic mutations that give rise to the specifi c drug metabolism phenotype. ...