Textbook of Personalized Medicine - Second Edition [2015]

19 Pharmacoproteomics is the application of proteomics to drug discovery and development. Discovery of protein biomarkers may s ...

20 Relationship of Various Technologies to Personalized Medicine Relationship of various technologies to personalized medicine i ...

21 Evidence-based medicine supports a standardized application of therapy that does not take into account variations of respons ...

22 relevant in decisions about prescribing. Ultimately, pharmacogenetics may be a much greater driving force for the application ...

23 Genome- wide association studies (GWAS) have identifying approximately several loci for common diseases and traits. These ass ...

24 phenotypes. GeneClinics ( http://www.geneclinics.org/ ) helps clinicians to relate the information from genetic testing to th ...

25 Genetic Epidemiology Genetic epidemiology is the study of the etiology, distribution, and control of disease in groups of rel ...

26 Role of Systems Biology in Personalized Medicine Systems biology is defi ned as the biology of dynamic interacting networks. ...

27 The National Institute of General Medical Sciences (NIGMS), which has created two National Centers for Systems Biology in the ...

28 Systems Medicine The concept of systems biology is applied to systems medicine and is relevant to personalized medicine. Comp ...

29 Systems approach will enable medicine to become predictive, personalized, preventive and participatory, and, in the process, ...

30 1 bp in the target DNA, and recognition sequences of TAL effectors are predictable (Boch et al. 2009 ). The modular protein a ...

31 Reclassifi cation of Diseases Because all major diseases have a genetic component, knowledge of genetic basis helps in distin ...

32 Translational Science and Personalized Medicine Translational science or medicine means applications of research fi ndings fo ...

33 Goldberger JJ, Buxton AE. Personalized medicine vs guideline-based medicine. JAMA. 2013; 309:2559–60. Hastings PJ, Lupski JR, ...

K.K. Jain, Textbook of Personalized Medicine, DOI 10.1007/978-1-4939-2553-7_2, 35 © Springer Science+Business Media New York 201 ...

36 Molecular Diagnostic Technologies Molecular diagnostic technologies have been reviewed in a detailed report on this topic (Ja ...

37 mutation detection overlap with technologies for detection of single nucleotide polymorphisms (SNPs) described later in this ...

38 Denaturing High-Performance Liquid Chromatography Denaturing high-performance liquid chromatography (DHPLC) is a PCR-based me ...

39 Difference in size is usually referred to as restriction fragment length polymorphism (RFLP). The size of the products is eas ...