Logistic Regression: A Self-learning Text, Third Edition (Statistics in the Health Sciences)

Introduction Our discussion of matching begins with a general descrip- tion of the matching procedure and the basic features of ...

Objectives Upon completion of this chapter, the learner should be able to: State or recognize the procedure used when carrying ...

Presentation I. Overview FOCUS Basics of matching Model for matched data Control for con- founding and inter- action Examples fr ...

Category matching: Combined set of cate- gories for case and its matched control Factor A: Factor B: Factor Q: AGE:20–29 30–39 4 ...

Disadvantage: Matching iscostly:  To find matches  Information loss due to discarding controls Safest strategy: Matching Match ...

Special case: Case-control study 100 matched pairs n¼ 200 100 strata¼100 matched pairs 2 observations per stratum 1st pair 2nd p ...

Stratum 1 Compute Mantel – Haenszel c^2 and MOR Stratum 2 Stratum 100 D E E D E WY E XZ E E E E E E E E D 101 D 101 D 011 D 011 ...

Analysis for R-to-1 and mixed matching use stratified analysis R-to-1 or mixed matching usew^2 MHandMORd for stratified data IV. ...

Logistic model for matched data includes control of variables not matched Stratified analysis inefficient: Data is discarded Mat ...

 SomeCs matched by design  RemainingCs not matched D¼ð 0 ; 1 Þdisease X 1 ¼E¼ð 0 ; 1 Þexposure Some Xs: V 1 i dummy variables ...

Matched pairs model: logit PðXÞ¼aþbEþ~g 1 iV 1 i þ~g 2 jV 2 jþE~dkWk ROR¼expbþ~dkWk  Note: Two types ofVvariables are controll ...

The study involves 117 persons in 39 matched sets, or strata, each strata containing 3 per- sons, 1 of whom is a case and the ot ...

One way to test for this interaction is to carry out a chunk test for the significance of both product terms considered collecti ...

Under this reduced model, the estimated odds ratio adjusted for the effects of theVvariables is given by the familiar expression ...

VI. Assessing Interaction Involving Matching Variables The previous section considered a study of the relationship between smoki ...

Using the above (option 1) interaction model, we can assess interaction of exposure with the matching variables by testing the n ...

Using the above (option 2) interaction model, we can assess interaction of exposure with the matching variables by testing the n ...

VII. Pooling Matching Strata To pool or not to pool matched sets? Case-control study:  Pair-match on SMK (ever vs. never)  100 ...

Ignore exchangeability?No!!! Treating such strata separately is artificial, i.e., exchangeable strata are not unique Analysis? P ...

Summary on pooling: Recommend:  Identify and pool exchangeable matched sets  Carry out stratified analysis or logistic regress ...