Comparative and Veterinary Pharmacology

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Interspecies Allometric Scaling Robert P. Hunter Contents 1 Introduction ....................................................... ...

does not wish to be the first to administer an agent or formulation in an untested species. “One medicine” is a central concept ...

species, and humans, relatively little is known of the physiology of the thousands of other vertebrate species. It is known that ...

due to the long gastrointestinal transit times of greater than one week in boid snakes (Secor et al. 1994 ), which allow for a x ...

to a nondomestic species is to use a dose based on body weight (mg/kg) established in the domestic species (i.e., dog, cat, catt ...

wherePmetis the metabolic power (rate of O 2 consumption if considered equivalent to the energy metabolism per unit time), 70 is ...

This ratio method uses an established dosage in a specific species and links the dosage to a physiological function instead of t ...

Recent data (Careau et al. 2007 ; Packard and Birchard 2008 ), however, question the assumption that basal metabolic rate can be ...

Although its use in zoo medicine has been limited, this approach may have advantages over the previously described methods. Appl ...

whereYis the pharmacokinetic parameters of interest,Wis body weight, anda andbare the coefficient and exponents of the allometry ...

While avian cytochrome P450 activities have been reported, their expression and role in avian drug metabolism are not well docum ...

Table 3Predicted and observed clearance (mL/min) in large animals with and without inclusion of a large animal based on simple a ...

extending application of the results in clinical cases. Clinicians should also care- fully consider interspecies differences in ...

that it is impossible to derive a single equation correlating body mass to metabolic rate for all 6,000 species of reptiles (Fun ...

Table 5 Body weight (kg) vs. organ weight (g/100 g BW). Values from Spector ( 1956 ) and adapted from Martinez et al. ( 2006 ) O ...