Comparative and Veterinary Pharmacology

2.1.2 Cytochrome P450 2D in Rats Unlike humans, who have only one functional CYP2D subfamily protein (i.e. CYP2D6), rats have si ...

2.1.4 Cytochrome P450 1A2 in Dogs A pre-clinical pharmacokinetic study of a novel cognitive enhancer (AC-3933) in Beagle dogs re ...

date, the incidence of this polymorphism in canine breeds other than Beagles has not been reported. 2.1.5 Cytochrome P450 2B11 i ...

group but not in the control group. Furthermore, the pharmacokinetics of thiopen- tone in phenobarbitone-treated animals followi ...

expression also accounts for decreased clearance of thiobarbiturates or other drugs in Greyhounds. 2.1.6 Esterases in Horses and ...

that had previously experienced an adverse reaction to procaine penicillin, com- pared with a matched control group of horses (F ...

2.2 Conjugative Enzymes 2.2.1 N-acetyltransferase in Mice, Rats, Hamsters, Rabbits and Rhesus Macaques In humans, slowN-acetyltr ...

the slow metaboliser phenotype. Again, functionally significant variants of the rat Nat1gene have not been identified and ratNat ...

developing gene therapy methods for the correction of monogenetic disorders (Miranda and Bosma 2009 ). 2.2.3 UDP-Glucuronosyltra ...

were discovered, with 12 of these accounting for 30% of the total variance in TPMT activities representing an approximately 10-f ...

theABCB1(formerlyMDR1) gene (See also chapter, “Drug Delivery Systems in Domestic Animal Species” Sect. 4).P-gp is an ATP-depend ...

used to define the role ofP-gp in drug disposition for preclinical drug development studies in dogs (Kitamura et al. 2008 ). Sho ...

deficient Mrp2 expression (Wright and Dickinson 2004 ; Leslie et al. 2007 ). The genetic basis for the defect involves a single ...

of genes including those encoding oxidative enzymes (such as CYP1A1) and conjugative enzymes (such as UGT1A6) (Poland et al. 199 ...

recognised that PSS/PSE might represent a form of malignant hyperthermia, as affected pigs also responded to inhalant anaestheti ...

including higher feed efficiency and greater yield of lean meat, although there was a higher incidence of PSE pork (Leach et al. ...

eventually isolated the causative mutation (c.1649t>c; p.V547A) within the canine RyR1gene. Interestingly, likeRyR1mutations ...

resistance to the toxic effects of these agents (Lasseur et al. 2007 ). It is thought that warfarin resistance is multifactorial ...

Aleman M, Nieto JE, Magdesian KG (2009) Malignant hyperthermia associated with ryanodine receptor 1 (C7360G) mutation in Quarter ...

Gillard EF, Otsu K, Fujii J, Khanna VK, de Leon S, Derdemezi J, Britt BA, Duff CL, Worton RG, MacLennan DH (1991) A substitution ...