Comparative and Veterinary Pharmacology

(Bousquet-Me ́lou et al. 2004 ) and thereby give rise to undesirable sub-therapeutic concentrations in both treated and untreate ...

Lees et al. ( 1986 ), Norgren et al. ( 2000 ) and Wennerlund et al. ( 2000 ) reported that untreated horses that were housed for ...

for esophageal smooth muscle. In addition, the oesophagus relaxes under the influence of oxytocic substances and this complicate ...

particles that require cellulose breakdown and the delay will be longer as the turnover time for the solid phase is approximatel ...

by the oral route and having a poor bioavailability and also extensively excreted in the bile (such as oxytetracycline) or by en ...

used in poultry. One likely reason for their high susceptibility in horses is their relative inability to demethylate compounds ...

Advances in molecular biology and pharmacogenetics has enabled more com- prehensive data to be obtained in the face of more prot ...

metabolism of antipyrine than beagles, resulting in a significantly longer half-life (greyhound 1.09 h, beagle 0.55 h) (KuKanich ...

typical in carnivores. In horses, the variability between animals may be very large (from pH 5 to 9) and urinary pH displays a b ...

drinking water should take account of the species specific daily water consumption. In addition, within a given species, many bi ...

is a metabolic adaptation observed in wild migrating birds and fish (e.g. cod), in which hepatic steatosis occurs naturally as a ...

Biliary elimination and enterohepatic recycling of drugs occur in fish. Topical treatments are available and fish may be placed ...

13 Conclusions The main conclusion from this review is that differences between species are numerous and often unpredictable in ...

Court MH, Hay-Kraus BL, Hill DW, Kind AJ, Greenblatt DJ (1999) Propofol hydroxylation by dog liver microsomes: assay development ...

Langford DJ, Crager SE, Shehzad Z, Smith SB, Sotocinal SG, Levenstadt JS, Chanda ML, Levitin DJ, Mogil JS (2006) Social modulati ...

Popot MA, Menaut L, Boyer S, Bonnaire Y, Toutain PL (2007) Spurious urine excretion drug profile in the horse due to bedding con ...

Comparative and Veterinary Pharmacogenomics Carrie M. Mosher and Michael H. Court Contents 1 Introduction ...................... ...

response variability phenotypes with either known genetic aetiology or strong circumstantial evidence for genetic involvement. P ...

29 mammalian species, including dog, cat, rat, rabbit, horse, cow, sheep, and pig (seehttp://www.ncbi.nlm.nih.gov/genomes/static ...

of in vitro celecoxib hydroxylase activity in liver microsomal preparations from representative EM and PM phenotyped dogs showed ...