Vertebrate Development Maternal to Zygotic Control (Advances in Experimental Medicine and Biology)

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© Springer International Publishing Switzerland 2017 441 F. Pelegri et al. (eds.), Vertebrate Development, Advances in Experimen ...

442 activation begins. These events, along with clearance of maternal RNAs and proteins, define the maternal to zygotic transiti ...

443 The terms MBT and MZT (maternal to zygotic transition) have been used vari- ously. We follow the clear definitions in Tadros ...

444 Many metazoans, including nonmammalian vertebrates, undergo a cleavage stage, though cell cycle timing varies (Table 9.1). I ...

445 association with cyclin proteins and phosphorylation state. Furthermore, subcellular localization and degradation of cyclin ...

446 oogenesis, and cyclin protein accumulation is posttranscriptionally regulated. Cell cycle phase-specific translation of cycl ...

447 partial activation of mitotic events. These data suggest that cyclin accumulation alone is not enough to mediate all aspects ...

448 DNA damage response proteins, promoting DNA repair and checkpoint signal ampli- fication (Sirbu and Cortez 2013 ). γH2AX is ...

449 their destruction, which is required for anaphase onset and mitotic exit (Amon et al. 1994 ; Lara-Gonzalez et al. 2012 ). De ...

450 Fig. 9.1 N:C Ratio Model. (a) The N:C ratio model argues for a maternally provided inhibitor (I) of an activity (A), for exa ...

451 with exogenous DNA, advances the timing of the MBT (Dasso and Newport 1990 ; Newport and Kirschner 1982a, b; Mita and Obata ...

452 showed that mutant embryos with increased maternal supplies of Cdc25 have one extra rapid, synchronous mitotic cycle. Conver ...

453 9.2.4.4 Developmental Use of the Replication Checkpoint for Cell Cycle Elongation Proteins involved in the cellular response ...

454 in cleavage-stage embryos. Eventually, a limiting amount of this replication factor leads to a delay in replication. While t ...