Exercise for Cardiovascular Disease Prevention and Treatment From Molecular to Clinical, Part 1

204 Perreault CL, Gonzalez-Serratos H, Litwin SE et  al (1993) Alterations in contractility and intracellular Ca2+ transients i ...

205 Schultz HD, Marcus NJ, Del Rio R (2015) Mechanisms of carotid body chemoreflex dys- function during heart failure. Exp Phys ...

206 Wang WZ, Gao L, Wang HJ et al (2009) Tonic glutamatergic input in the rostral ventrolateral medulla is increased in rats wi ...

© Springer Nature Singapore Pte Ltd. 2017 207 J. Xiao (ed.), Exercise for Cardiovascular Disease Prevention and Treatment, Advan ...

208 Rubler et al. [ 3 ] have first described cardiomyopathy in a small cohort of diabetics with post-mortem adverse myocardial s ...

209 Several studies have demonstrated the effect of exercise on substrate utilization in normal, obese and diabetic myocardium. ...

210 storage enzyme) [ 46 ]. Bilet et  al. [ 47 ] demonstrated that acute bout of exercise increased plasma FFAs levels and cardi ...

211 5 Effect of Exercise on Hyperglycemia-Induced Cellular Pathways in the Myocardium Hyperglycemia can aggravate cardiovascular ...

212 ROS [ 84 ]. In addition, activation of the polyol pathway has been reported to predis- pose the cardiac tissue to ischemic i ...

213 (UDP)-N- acetylglucosamine which is used by the enzyme O-linked N-acetylglucosamine transferase (O-GlcNAc) to modify serine ...

214 6.2 Exercise Attenuates ROS Generation via Mitochondrial Electron Leakage In oxidative phosphorylation, the transfer of elec ...

215 [ 123 – 125 ]. Although not fully understood, this transient increase has been suggested to be mediated through rigorous car ...

216 modulates multiple redox-sensitive proteins and signaling pathways [ 131 ]. The interaction between cytochrome b558 and the ...

217 2 diabetic rats after long-term endurance training. In the study of Sharma et  al. [ 138 ], type 2 diabetic rats underwent a ...

218 The acute effects of exercise on cardiac NOS isoforms in diabetes are not fully understood. However, long-term exercise has ...

219 6.7 Effects of Exercise on AGEs-Induced ROS Glycation is the non-enzymatic covalent bonding to glucose to proteins and lipid ...

220 vasculature- protecting effects of exercise are mediated, at least in part, through sup- pression of glycation. Another stud ...

221 8 Concluding Remarks Exercise exerts beneficial cardiac effects and influences several metabolic changes associated with dia ...

222 References Rydén L, Grant PJ, Anker SD et al (2013) ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases d ...

223 Belke DD, Larsen TS, Gibbs EM et  al (2000) Altered metabolism causes cardiac dys- function in perfused hearts from diabeti ...