Systems Biology (Methods in Molecular Biology)

change of the subsystems as well (e.g., genetic instability). From this point of view cancer can be considered a disease of the ...

distinction between intrinsic and extrinsic properties. Without going too much into metaphysical details, we define a property F ...

different contexts. Through this, they can actually infer, for instance, a causal relationship between a mutation and a cellular ...

the metabolic network as a whole. Here, two concurrent non-lethal events acquire an essential property, lethality, from the exis ...

of a given morphogenic. When the structure of a tissue is affected, cells are “disoriented” and no longer constrained, they cann ...

gradient-based control, irrespective of the presence, or absence, of genetic mutations in cancer cells, during the initial neopl ...

embryogenesis are similar under certain respects, important differ- ences must also be acknowledged, as demonstrated by experime ...

6 Notes In this paper we do not commit to any specific notion of emergence. This is a topic that would deserve a paper alone. I ...

at the post-transcriptional level. Stem cells express specific pro- files of miRNAs that, in turn, can alter the cells’ differen ...

Sonnenschein C, Soto AM (1999) The society of cells: cancer and control of cell proliferation. Springer, New York Soto AM, Sonn ...

Chapter 2 An Integrative Approach Toward Biology, Organisms, and Cancer Carlos Sonnenschein and Ana M. Soto Abstract Over the la ...

variety of organisms. In this context, just two principles, namely, the generation of variation through reproduction and natural ...

not interchangeable. Their trajectories are generic and are not specified by the phase space [2]. Moreover, organisms are the re ...

relationship between the organism and cells. This means that a zygote is both a cell and an organism, and with each cell divisio ...

closure of constraints as the means to achieve and maintain stability was traditionally applied to intracellular processes. Moss ...

the interdependence of the parts in an organism, it is insufficient to analyze a single constraint or a given set of constraints ...

organisms, (2) the epistemological basis of the exact sciences (Phys- ics and Mathematics), and (3) the conceptual nuances in th ...

3.2 How Does the Above Narrative Relate to Empirical Evidence? A widely used model in carcinogenesis consists of the treatment o ...

researchers under the leadership of Beatrice Mintz verified the normalization of these teratocarcinoma cells when they were plac ...

Phenotypes of epithelial cells are susceptible of being manipu- lated experimentally by changing the niche (epithelium/stroma) i ...