Systems Biology (Methods in Molecular Biology)

basic principles of default state and the intrinsic constraints gener- ated by the epithelial cells. By identifying constraints ...

Sonnenschein C (2016) Toward a theory of organisms: three founding principles in search of a useful integration. Prog Biophys Mo ...

Chapter 3 Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation Andras Paldi Abstract The cells o ...

made necessary, among others, by the rapid evolution of techniques with single-cell resolution. Perhaps this is the reason why v ...

provide a solution for fundamental philosophical issues, but under- standing the origin and true significance of the concepts di ...

expression levels are the coordinates that determine the exact posi- tion. Statistical analysis of the distances between these p ...

3 Temporal Dynamics, Stability, and Change Single-cell studies uncovered another important aspect of the cel- lular phenotypes: ...

opposite of the traditional deterministic view, which has dominated biology until now. Obviously, change and stability are a pai ...

product in the cell is determined by the rate of the synthesis and degradation [28]. Simultaneous high synthesis and degradation ...

transcription factors can selectively bind to the DNA in a sequence- dependent way and further bias the equilibrium toward the o ...

processes. Indeed, the substrates used for epigenetic modification are all small molecular intermediates of the core energy meta ...

The direct dependence of the stabilizing mechanisms on the energy-producing metabolic flux also implies that the cellular envi- ...

the generation of new phenotypic variants until the metabolic adaptation is achieved. The Darwinian model of cell differentiatio ...

Robson P, Niakan KK (2015) Defining the three cell lineages of the human blastocyst by single-cell RNA-seq. Development 142 (18) ...

proteome. Bioessays 35(7):597–601.https:// doi.org/10.1002/bies.201300017 Misteli T (2001) Protein dynamics: implica- tions for ...

Chapter 4 A Primer on Mathematical Modeling in the Study of Organisms and Their Parts Mae ̈l Monte ́vil Abstract Mathematical mo ...

We want to emphasize the difference between mathematical models on the one side and theories on the other side. Of course, model ...

particular constraints, input, or signal. We think that proliferation with variation and motility should be used as a default st ...

a model of an in vitro experiment even though it is relevant for the very survival of the cells studied. Of course, there is usu ...

understanding them is of paramount importance to understand the assumptions of a model. The basic rule of modeling is extremely ...