Systems Biology (Methods in Molecular Biology)
Dozmorov MG (2009) Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells. Prostate 69 (10): ...
Webb BA, Chimenti M, Jacobson MP, Barber DL (2011) Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer 11 ( ...
Potter VR, Watanabe M, Pitot HC, Morris HP (1969) Systematic oscillations in meta- bolic activity in rat liver and hepatomas. S ...
Chapter 9 Complexity of Biochemical and Genetic Responses Reduced Using Simple Theoretical Models Kumar Selvarajoo Abstract Livi ...
especially for overcoming diseases, where therapeutic targets can be developed to control specific biochemical aberrations. Bioc ...
aerospace industries. Similarly, in thermodynamics related to gas flows, the ideal gas law (the popularPV¼nRTequation), although ...
2 Modeling Biochemical Reactions 2.1 Mass Action Kinetics The earliest research in biochemical reactions, around the mid-1800s, ...
dA½ dt ¼k 2 ½A^2 ð 3 Þ wherek 2 is the second-order rate constant. It has dimensions of (mol/L)^1 s^1. A chemical reaction ...
EþA$ k 1 k 1 EA! kcat EþB In this case, the rate ofBformation can be shown to be (see ref.8 for detailed derivation): dB dt ¼ V ...
concentration of the connected species are governed by the generalized kinetic evolution equation: ∂Xi ∂t ¼FiðÞX 1 ;X 2 ;...;Xn, ...
Fig. 3Simulations for (A) mass-action, (B) Michaelis-Menten (M-M) kinetics, and (C) Michaelis-Menten kinetics with reversible re ...
any set of positive real parameter values. Note that we do not use negative or complex numbers for parameter values for biochemi ...
Fig. 4Linear response observed in cellular dynamics. (a) Glycolysis, adapted from [9], (b) Epidermal growth factor (EGF) signali ...
higher-order mass-action, enzyme kinetic equations, or simply Boolean logics, depending on the knowledge gained for an individ- ...
However, the observation of periodic and synchronized oscillations in laboratory yeast glycolysis in the late 1950s, subsequentl ...
The B-Z reaction mechanism, a nonlinear chemical oscillator, serves as an example for non-equilibrium thermodynamics. The Brusse ...
X 1! k 4 D These reactions lead to the following ordinary differential equations: dX 1 dt ¼k 1 Ak 2 BX½þ 1 k 3 ½X 12 ½X 2 k ...
proteins, Brian C. Goodwin developed, in 1965, a highly simplified regulatory network with a negative feedback mechanism to disp ...
simple six coupled linear differential equations model approximat- ing the gene regulatory network of repressing genes, they inv ...
Fig. 9A synthetic biological oscillator. (a) Simulations of oscillator with initial conditions and parameters, see insert.(b) Ti ...
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