Stem Cell Microenvironments and Beyond

113 Méndez O, Zavadil J, Esencay M, Lukyanov Y, Santovasi D, Wang S-C et al (2010) Knock down of HIF-1α in glioma cells reduces ...

114 O’Leary CJ, Bradford D, Chen M, White A, Blackmore DG, Cooper HM (2015) The netrin/RGM receptor, neogenin, controls adult ne ...

115 Qiang L, Wu T, Zhang H-W, Lu N, Hu R, Wang Y-J et al (2012) HIF-1alpha; is critical for hypoxia- mediated maintenance of gli ...

116 Sirko S, von Holst A, Weber A, Wizenmann A, Theocharidis U, Götz M et al (2010) Chondroitin sulfates are required for fibrob ...

117 Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD et al (2014a) Axonal con- trol of the adult neural stem ...

118 Yamashita T, Ninomiya M, Hernandez Acosta P, Garcia-Verdugo JM, Sunabori T, Sakaguchi M et  al (2006) Subventricular zone-de ...

© Springer International Publishing AG 2017 119 A. Birbrair (ed.), Stem Cell Microenvironments and Beyond, Advances in Experimen ...

120 7.1 Introduction 7.1.1 Disease Classification and Histopathology Glioblastoma (GBM) is classified according to the 2007 WHO ...

121 astrocytes and pericytes which wrap around endothelial cell tight junctions (Abbott 2002 ; Abbott et al. 2010 ; Agarwal et a ...

122 7.2 Discovery of Cancer Cells Expressing Stem Cell Surface Markers A stochastic model in which all cancer cells possessed si ...

123 cells and terminally differentiated cells were considered lower in hierarchy (Nguyen et al. 2012 ; Dick 2009 ; Cabrera et al ...

124 (Heddleston et al. 2011 ). GSCs have also recently been shown to transdifferentiate into endothelial cells (Heddleston et al ...

125 transform upon genetic mutations and microenvironmental cues to give rise to CSCs (Hanahan and Weinberg 2011 ; Friedmann-Mor ...

126 7.3 Role of the Neural Stem Cell Niche in the Origin and Maintenance of Glioblastoma Stem Cells Arising from Aberrant Stem a ...

127 tightly regulated balance of various components of the neural stem cell niche that are responsible for maintaining NSCs. Dys ...

128 GBMs due to endothelial derived factors (Heddleston et  al. 2011 ; Jhaveri et  al. 2016 ). In addition, CD133+ GSC populatio ...

129 been shown to interfere with the transdifferentiation of GSCs into endothelial cells and increased their sensitivity to radi ...

130 normal tissue from effects of hypoxia (Brat et al. 2004 ). Hypoxia and the activation of hypoxia response genes are thought ...

131 in increasing mutational rate in tumors by reducing levels of mismatch repair pro- tein (mutS) and promoting glucose flux th ...

132 and its cellular receptor integrin α 6 β1 in GBM cells has been reported to promote tumor progression (Huang et  al. 2012 ). ...