Stem Cell Microenvironments and Beyond

133 7.5 Future Directions Standard forms of therapy have been ineffective in significantly increasing the over- all survival of ...

134 to target GSC specific biomarkers and angiogenic blood vessels might therefore prove to be ineffective in future. The recent ...

135 Brat DJ, Castellano-Sanchez AA, Hunter SB et  al (2004) Pseudopalisades in glioblastoma are hypoxic, express extracellular m ...

136 Folkins C, Shaked Y, Man S et al (2009) Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascu ...

137 Jordao JF, Thevenot E, Markham-Coultes K et al (2013) Amyloid-beta plaque reduction, endog- enous antibody delivery and glia ...

138 Murat A, Migliavacca E, Gorlia T et al (2008a) Stem cell–related “Self-Renewal” signature and high epidermal growth factor r ...

139 Scadden DT (2006) The stem-cell niche as an entity of action. Nature 441(7097):1075–1079 Scheres B (2007) Stem-cell niches: ...

140 Wang CY, Mayo MW, Baldwin AS Jr (1996) TNF- and cancer therapy-induced apoptosis: poten- tiation by inhibition of NF-kappaB. ...

© Springer International Publishing AG 2017 141 A. Birbrair (ed.), Stem Cell Microenvironments and Beyond, Advances in Experimen ...

142 way for the development of novel cell and gene therapies, in vitro disease models and preclinical drug testing paradigms. He ...

143 The myocytes subsequently fuse in order to form new or repair existing myofibers (depending on the severity of injury). The ...

14 4 ROSA-YFP mice, Kuang et al. found that the majority of SCs are Pax7+/Myf5+, and only small subset are Pax7+/Myf5− cells (Ku ...

145 EC PEC Ang1 Calc Serpin, Tfpi2, Timpf4 Laminin-2 Fibronectin Calcr Tie-2 Integrin α7β1 M-Cadherin MA FI MF qSC FAP BL RL Fig ...

146 EC PEC Cytokine c-Met CXCR4 Syndecan 4 Frizzled 7 MMPs SDF-1 Wnt7a GF HGF Fibronectin Delta Notch receptor Integrin α7β1 Lam ...

147 These growth factors, including fibroblast growth factors (FGFs), epidermal growth factor (EGF), insulin-like growth factors ...

148 through that action liberate ECM-bound HGF, allowing its binding to the c-Met receptor on SCs. This HGF signaling through c- ...

149 to glycolytic fast-twitch myofibers (Gibson and Schultz 1982 ). Moreover, a similar difference in SC numbers can be achieved ...

150 in resting SCs. This interaction in turn induces the expression of quiescence markers and blocks the expression of different ...

151 in the number of muscle tissue fibroblasts is a hallmark of muscle regeneration (Serrano et al. 2011 ). Furthermore, interac ...

152 CX3CR1), which prevent apoptosis of myogenic cells (Sonnet et al. 2006 ). Apart from innate immunity, cells of the adaptive ...