Stem Cell Microenvironments and Beyond

11 the osteoblastic lineage have increased HSC numbers (Calvi et  al. 2003 ; Zhang et  al. 2003 ) strongly suggested that osteob ...

12 et al. 2014 ; Nakamura-Ishizu et al. 2014 , 2015 ; Yamazaki et al. 2011 ; Zhao et al. 2014 ); or retention (e.g. macrophages ...

13 circulation (Itkin et al. 2016 ). Kusumbe et al., has also shown that arterioles support HSPC.  Constitutive activation of th ...

14 These hematopoietic progenitors also depend on signals from the microenviron- ment for maintenance and differentiation but th ...

15 Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma’ayan A, Frenette PS (2017a) Differential cytokine contrib ...

16 Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K et a ...

17 Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R et  al (2011) O ...

18 Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA et a ...

© Springer International Publishing AG 2017 19 A. Birbrair (ed.), Stem Cell Microenvironments and Beyond, Advances in Experiment ...

20 3.1 Introduction The dynamic interactions between leukemic cells and bone marrow (BM) cells in the leukemia BM microenvironme ...

21 Mendelson and Frenette 2014 ). Recent advances in microscopy and transgenic ani- mal models have revolutionized the understan ...

22 (Jin et al. 2006 ). Treg cells provide a relative immune sanctuary for stem cells on the endosteal surface and participate in ...

23 may reflect disruption of normal hematopoietic progenitor cell niches and creation of leukemia niches by leukemic cells (Colm ...

24 variant isoforms (CD44v), is a key regulator of LSC homing to BM niches and maintenance of their primitive state (Jin et al. ...

25 molecule- 1, to support vascular adhesion (Stucki et  al. 2001 ). It has been further demonstrated that INTEGRIN β 3 knockdow ...

26 3.2.6 LSC Metabolism Leukemia cells have two major metabolic challenges: how to meet the bioenergetic and biosynthetic demand ...

27 adhesion, provides growth factors, and promotes immunosuppression (Tabe and Konopleva 2014 ; Nwajei and Konopleva 2013 ). At ...

28 of leukemic cells is critically regulated by the transition mechanisms from stem to progenitor cell, corresponding to metabol ...

29 Colmone A, Amorim M, Pontier AL, Wang S, Jablonski E, Sipkins DA (2008) Leukemic cells create bone marrow niches that disrupt ...

30 Kiel MJ, Morrison SJ (2008) Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol 8:290–301 Koh ...