Organ Regeneration Based on Developmental Biology

69 transdifferentiation of supporting cells, and the molecular mechanisms underlying them may also be investigated within this i ...

70 Brugmann S, Pandur P, Kenyon K, Pignoni F, Moody S (2004) Six1 promotes a placodal fate within the lateral neurogenic ectoder ...

71 Leung A, Morest D, Li J (2013) Differential BMP signaling controls formation and differentiation of multipotent preplacodal e ...

72 Sato T, Vries R, Snippert H (2009) Single Lgr5 stem cells build crypt–villus structures in  vitro without a mesenchymal niche ...

© Springer Nature Singapore Pte Ltd. 2017 73 T. Tsuji (ed.), Organ Regeneration Based on Developmental Biology, DOI 10.1007/978- ...

74 5.1 Introduction The tooth is of ectodermal organ whose development is regulated by reciprocal epithelial-mesenchymal interac ...

75 Sharpe and Young 2005 ). It is anticipated that whole-tooth replacement therapy will be established in the near future as a n ...

76 Tooth root formation is initiated after tooth crown formation, and the mature teeth erupt into the oral cavity (Avery 2002 ; ...

77 of tooth tissue-derived stem cells, which can differentiate along various dental-cell lineages, forming odontoblasts, pulp ce ...

78 A) Periodontal tissue Regeneration PDLSCs, DFPCs Dentin / Pulp tissue regeneration PDGF, bFGF, IGFs, BDNF, ADAMTSL 6 b Stem C ...

79 tissue, are able to have a highly proliferative capacities and to differentiate into all of the periodontal cell types after ...

80 (Finkelman et  al. 1990 ; Cassidy et  al. 1997 ; Roberts-Clark and Smith 2000 ; Zhao et al. 2000 ; Sloan and Smith 1999 ; Dob ...

81 5.4 Technological Development for Whole-Tooth Regeneration Utilising a Novel Three-Dimensional Cell-Manipulation Method Stem- ...

82 of whole- tooth regeneration, the first major issue is considered to be developing a three- dimensional cell-manipulation tec ...

83 In the dental field, many researchers have isolated the dental epithelial and mesen- chymal tissues from embryonic tooth germ ...

84 Furthermore, an attractive concept for generating a bioengineered tooth unit composed of a mature tooth, PDL and alveolar bon ...

85 partitioned periodontal tissue structure (Fig. 5.4b). In the case of edentulous jaw or following segmental mandibulotomy, it ...

86 A) Bioengineered tooth eruption Day 16 Day 37 Day 49 Bioengineered tooth occlusion B) NT BT PDL NT AB BT PDL Occlusion of a b ...

87 The success in the transplantation of bioengineered mature organs is whether they can exert the immediate organ performance o ...

88 tooth units, is required for the functional recovery of perceptive potential against noxious stimuli in future tooth regenera ...