Organ Regeneration Based on Developmental Biology

151 Tucker AS, Headon DJ, Courtney JM, Overbeek P, Sharpe PT (2004) The activation level of the TNF family receptor, Edar, deter ...

© Springer Nature Singapore Pte Ltd. 2017 153 T. Tsuji (ed.), Organ Regeneration Based on Developmental Biology, DOI 10.1007/978 ...

154 Therefore, a deeper understanding of the key signals required for lineage specifica- tion in vivo is essential for the induc ...

155 pronephros mesonephros metanephros Fig. 9.1 Schematic of an E10.5 embryo. The kidney develops from three distinct primordia— ...

156 secreted by nephron progenitor cells to signal via the tyrosine kinase receptor ret proto-oncogene (Ret) on the ureteric epi ...

157 differentiation (Das et al. 2013 ; Mendelsohn et al. 1999 ). Therefore, the interactions among the UB, metanephric nephron p ...

158 In summary, canonical Wnt signaling plays a central role in the initiation of nephron progenitor differentiation, whereas th ...

159 9.5 Early Kidney Specification All somatic tissues develop from the epiblast of the fertilized egg (E5.5 in mice). At E6.5 t ...

160 9.5.2 Lateral Patterning of the IM During Post-migration In addition to the pre-patterning within the PS (before migration), ...

161 level of BMP signaling for subsequent IM marker gene expression following in vitro culture of the presomitic mesenchyme and ...

162 Thus, similar to the process of somitogenesis, the IM develops in an anterior- to- posterior direction alongside caudal trun ...

163 9.5.4 Mechanism of A-P Axis Formation Along the Body Trunk Elongation During embryogenesis, formation of the rostral body tr ...

16 4 mice exhibit caudal truncation of the embryo (Takada et al. 1994 ; Yamaguchi et al. 1999 ). Contrastingly, cells undergo di ...

165 9.5.5 UB and MM Differentiate from a Caudal T+ Population at Different Times A lineage tracing experiment utilizing Osr1-GFP ...

166 Oct3/4 ES/iPS T Nascent Mesoderm T Hox1 1 Posterior Nascent Mesoderm Osr1 Wt 1 Hox11 Posterior Intermediate Mesoderm Osr1 Wt ...

167 9.6 Induction of Metanephric Nephron Progenitors from Pluripotent Stem Cells In contrast to conventionally accepted Nodal−/a ...

168 employs embryonic spinal cord and Wnt4-expressing 3T3 feeder cells efficiently differentiates both mouse and human PSC-deriv ...

169 (WT1, MAFB, FOXD1, TCF21, and VEGFA), typical slit diaphragm-related genes (NPHS1, NPHS2, CD2AP, CLIC5, and dendrin), basola ...

170 Table 9.1 Genes common to iPS-derived podocytes in  vitro, human glomeruli, and mouse podocytes in vivo Gene Symbol Gene nam ...

171 9.8 Applications Toward the Disease Modeling It is now possible to effectively induce metanephric nephron progenitor cells f ...