Catalyzing Inquiry at the Interface of Computing and Biology

A COMPUTATIONAL AND ENGINEERING VIEW OF BIOLOGY 219 Kitano makes the point that robustness is a property of an entire system;^38 ...

220 CATALYZING INQUIRY good protocol being its ability to support both robustness and evolvability, a key consideration in techn ...

A COMPUTATIONAL AND ENGINEERING VIEW OF BIOLOGY 221 A second useful construct from signal processing is the bandpass filter, whi ...

222 CATALYZING INQUIRY neity and diversity. For example, noise (in the form of molecular fluctuations) introduced into the genet ...

A COMPUTATIONAL AND ENGINEERING VIEW OF BIOLOGY 223 two antagonistic feedback loops that create a switch and molecular fluctuati ...

224 CATALYZING INQUIRY information abstractions can be used to communicate about or to explain biological processes and concepts ...

A COMPUTATIONAL AND ENGINEERING VIEW OF BIOLOGY 225 concurrency, multilevel description, and object orientation, Kam et al. cons ...

226 CATALYZING INQUIRY identification of specific words), syntactic (the grouping of words into grammatically correct phrases), ...

CYBERINFRASTRUCTURE AND DATA ACQUISITION 227 227 7 CYBERINFRASTRUCTURE AND DATA ACQUISITION 7.1 CYBERINFRASTRUCTURE FOR 21ST CEN ...

228 CATALYZING INQUIRY datasets dynamically. They must provide robust search capabilities so that researchers can find the datas ...

CYBERINFRASTRUCTURE AND DATA ACQUISITION 229 Box 7.1 A Cyberinfrastructure View: Envisioning and Empowering Successes for 21st C ...

230 CATALYZING INQUIRY managing, and connecting data from various modalities and on multiple scales of biological systems, from ...

CYBERINFRASTRUCTURE AND DATA ACQUISITION 231 7.1.3 The Role of High-performance Computing Loosely speaking, processing capabilit ...

232 CATALYZING INQUIRY Many biological applications must access large amounts of data. Furthermore, because of the combinatorial ...

CYBERINFRASTRUCTURE AND DATA ACQUISITION 233 Box 7.3 Grand Challenges in Computational Structural and Systems Biology The Onset ...

234 CATALYZING INQUIRY solution often result in different estimates for the required computing power, and for any complex proble ...

CYBERINFRASTRUCTURE AND DATA ACQUISITION 235 with exponential improvements in computational speed, methods other than exhaustive ...

236 CATALYZING INQUIRY and age-matched controls. Some of the depression patients go on to develop Alzheimer’s disease (AD) and t ...

CYBERINFRASTRUCTURE AND DATA ACQUISITION 237 7.2 DATA ACQUISITION AND LABORATORY AUTOMATION As noted in Chapter 3, the biology o ...

238 CATALYZING INQUIRY troscopy today allow 1,000 proteins per day to be analyzed in an automated fashion, and there is hope tha ...