Catalyzing Inquiry at the Interface of Computing and Biology

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 179 Box 5.17 Computational Perspectives on Dopamine F ...

180 CATALYZING INQUIRY FIGURE 5.16 Bursting in the pre-Botzinger complex. Panel 1: Example of voltage-dependent properties of pr ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 181 PANEL 2 FIGURE 5.16 Continued Panel 2: Gating and ...

182 CATALYZING INQUIRY PANEL 3 FIGURE 5.16 Continued Panel 3: Projection of trajectory onto fixed points of fast subsystem. The ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 183 puter-aided methods for extracting accurate surfa ...

184 CATALYZING INQUIRY Box 5.18 The MCell Simulator MCell is a general Monte Carlo simulator of cellular microphysiology. MCell ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 185 FIGURE 5.17 Constructing the geometry of a chick ...

186 CATALYZING INQUIRY FIGURE 5.18 Summary of synaptic transmission simulations. (A) Location of selected transmitter release si ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 187 least constrained, are least understood, and have ...

188 CATALYZING INQUIRY subjects, deformations were localized to hippocampal subregions that send projections to the prefrontal c ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 189 deformities in subjects with DAT was largely symm ...

190 CATALYZING INQUIRY Box 5.19 Modeling the In Vivo Dynamics of HIV-1 Infection Mathematical models of HIV infection and treatm ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 191 takes a very long time, and individuals who have ...

192 CATALYZING INQUIRY agent and an individual (e.g., an insect that bites an individual) or between individuals (e.g., an indi- ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 193 users exhibit different dynamical patterns than t ...

194 CATALYZING INQUIRY Among the fundamental questions in the study of evolution are those that seek to know the relative streng ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 195 of the system. “The challenge, then, is to develo ...

196 CATALYZING INQUIRY Box 5.23 Genetic Complexities in Evolutionary Processes The dynamics of alleles at single loci are well u ...

COMPUTATIONAL MODELING AND SIMULATION AS ENABLERS FOR BIOLOGICAL DISCOVERY 197 Along these lines, a particularly interesting wor ...

198 CATALYZING INQUIRY virus vectors was modeled, each with different transmission efficiencies, rather than assuming a single v ...