Cannabinoids

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 257 3.2 Ligand–Receptor Studies f ...

258 P.H. Reggio In the non-classical CBs, Melvin has also shown that the phenolic hydroxyl at C-2′(see drawing of 2 ) is not nec ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 259 3.3.2 Side Chain In tradition ...

260 P.H. Reggio 4.1 Endocannabinoid SAR 4.1.1 Acyl Chain SAR While the fatty acid literature indicates that unsaturated fatty ac ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 261 been met with little success ...

262 P.H. Reggio (Ki= 7.3 nM) than anandamide itself (Ki= 22 nM) (Pinto et al. 1994; Sheskin et al. 1997). Substitution of an N-c ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 263 tricyclic ring structure of 2 ...

264 P.H. Reggio double bonds and saturation in at least the last five carbons of the acyl chain (Reg- gio and Traore 2000). Endo ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 265 bonds, respectively. This bin ...

266 P.H. Reggio One way to resolve the ambiguity concerning the bioactive conformation of the AAIs is by the development of rigi ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 267 Eissenstat et al. involved th ...

268 P.H. Reggio C-3 side chain of∆^9 -THC ( 1 ) and the morpholino group of 3 with the carbocyclic ring system of 1. A similar a ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 269 Most recently, Huffman synthe ...

270 P.H. Reggio CB templates and the identification of different AAI functional groups as key for interaction at CB 1. Importanc ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 271 respect to SR141716A and that ...

272 P.H. Reggio achieved by matching the oxygen atom of the morpholino ring or hydroxy moiety with the northern aliphatic hydrox ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 273 antagonistic activities and i ...

274 P.H. Reggio Adams IB, Ryan W, Singer M, Razdan RK, Compton DR, Martin BR (1995a) Pharmacological and behavioral evaluation o ...

Cannabinoid Receptors and Their Ligands: Ligand–Ligand and Ligand–Receptor Modeling Approaches 275 Devane WA, Dysarz FA, 3rd, Jo ...

276 P.H. Reggio Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, Razdan RK, Martin BR, Abood ME (1999) An investigati ...