Cannabinoids
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 155 Virodhamine, which seems to accompany AEA in all t ...
156 V. Marzo et al. 2.5 Endocannabinoid Release After their biosynthesis, AEA and 2-AG are immediately released into the extrace ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 157 above). This hypothesis is supported by evidence t ...
158 V. Marzo et al. Substances that inhibit the EMTenhanceresponses to exogenous AEA that are elicited at extracellular sites ( ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 159 membranes;whatwasoriginallythoughttobethehydrophob ...
160 V. Marzo et al. ride treatment (Di Marzo et al. 1999a). A MAGL with enzymatic properties and subcellular distribution very s ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 161 some lipoxygenase products being still capable of ...
162 V. Marzo et al. Fig. 4.Chemical structures of inhibitors of endocannabinoid biosynthesis or inactivation ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 163 been tested against PLA 2 enzymes. Among the FAAH ...
164 V. Marzo et al. al. 2004; Ronesi et al. 2004). The major drawback of VDM11 and VDM13 is that, like AM404, they are not very ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 165 Assays that measure the ability of ligands to inh ...
166 V. Marzo et al. detected in vascular endothelial cells. This putative receptor mediates the local vasodilator (but not the s ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 167 may reveal that TRPV1-mediated effects of AEA can ...
168 V. Marzo et al. receptors has not been addressed experimentally. Interestingly, a recent study showed that AEA, if administe ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 169 5 New Drugs from the Endocannabinoid System 5.1 Re ...
170 V. Marzo et al. –Inβ-amyloid-treated rats (a model of Alzheimer’s disease), in the hippocampus (authors’ own unpublished res ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 171 While enhanced signalling at CB 1 receptors contri ...
172 V. Marzo et al. Multiple sclerosis (Baker et al. 2001; de Lago et al. 2004b; C. Guaza and V. Di Marzo, unpublished observat ...
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids 173 To carry on identifying those disorders that can ...
174 V. Marzo et al. Bensaid M, Gary-Bobo M, Esclangon A, Maffrand JP, Le Fur G, Oury-Donat F, Soubrie P (2003) The cannabinoid C ...
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