Cannabinoids
196 W.-S.V. Ho and C.J. Hillard 3.4 Substrate Specificity of MGL MGL can hydrolyze both 1(3)- and 2-monoacylglycerols and has ve ...
Modulators of Endocannabinoid Enzymic Hydrolysisand Membrane Transport 197 3.5 Regulation of MGL Activity MGL activity in vitro ...
198 W.-S.V. Ho and C.J. Hillard culture (Farooqui et al. 1993) and in synaptoneurosomes prepared from young rat brain (Farooqui ...
Modulators of Endocannabinoid Enzymic Hydrolysisand Membrane Transport 199 FAAH-mediated catabolism (Deutsch et al. 2001; Glaser ...
200 W.-S.V. Ho and C.J. Hillard Table 4. Inhibitors of AEA cellular uptake Inhibitor Cell IC 50 (μM) Reference(s) Remarks AM404 ...
Modulators of Endocannabinoid Enzymic Hydrolysisand Membrane Transport 201 multiple sclerosis alone and can produce potentiation ...
202 W.-S.V. Ho and C.J. Hillard Bisogno T, Melck D, Bobrov M, Gretskaya NM, Bezuglov VV, De Petrocellis L, Di Marzo V (2000) N-a ...
Modulators of Endocannabinoid Enzymic Hydrolysisand Membrane Transport 203 DinhTP,CarpenterD,LeslieFM,FreundTF,KatonaI,SensiSL,K ...
204 W.-S.V. Ho and C.J. Hillard Hillard CJ, Jarrahian A (2000) The movement of N-arachidonoylethanolamine (anan- damide) across ...
Modulators of Endocannabinoid Enzymic Hydrolysisand Membrane Transport 205 Lio YC, Reynolds LJ, Balsinde J, Dennis EA (1996) Irr ...
206 W.-S.V. Ho and C.J. Hillard N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hy- drolase. Br J P ...
Modulators of Endocannabinoid Enzymic Hydrolysisand Membrane Transport 207 Thomas EA, Cravatt BF, Danielson PE, Gilula NB, Sutcl ...
HEP (2005) 168:209–246 ©cSpringer-Verlag 2005 Structural Requirements for Cannabinoid Receptor Probes G.A.Thakur·S.P.Nikas·C.Li· ...
210 G.A. Thakur et al. ments of cannabinoid receptor ligands and highlights their pharmacological and therapeutic potential. Key ...
Structural Requirements for Cannabinoid Receptor Probes 211 Extensive studies on the endocannabinoid system have revealed a numb ...
212 G.A. Thakur et al. 2 Classification of Cannabinoid Receptor Ligands 2.1 Classical Cannabinoids Classical cannabinoids (CCs) ...
Structural Requirements for Cannabinoid Receptor Probes 213 Fig. 2.Phenolic hydroxyl, B- and C-ring modified cannabinoid analogs ...
214 G.A. Thakur et al. Fig. 3.Representative C-1′side chain-modified analogs Fig. 4.Molecular modeling of (–)-∆^8 -THC ligands w ...
Structural Requirements for Cannabinoid Receptor Probes 215 Fig. 5.Representative side chain-modified analogs within the chain o ...
216 G.A. Thakur et al. Fig. 6.Cannabinoid analogs possessing a northern aliphatic hydroxyl (NAH) group an unfavorable orientatio ...
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