Synthetic Biology Parts, Devices and Applications

356 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering The modular nature of CAR signaling has also spurred ...

17.3 Synthetic Biology Approaches to Cellular Immunotherapy Engineering 357 receptors comprised of an extracellular scFv domain ...

358 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering lymphocytes (TILs) and restore T-cell function in ca ...

17.3 Synthetic Biology Approaches to Cellular Immunotherapy Engineering 359 molecules such as tumor growth factor-beta (TGF-β) o ...

360 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering interference with the intricate balance between immu ...

17.3 Synthetic Biology Approaches to Cellular Immunotherapy Engineering 361 constitutive IL-15 production and the inducible casp ...

362 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering In addition to the magnitude of the immune response, ...

17.4 Challenges and  uture utlook 363 technologies are poised to enable the generation of universal, off-the-shelf cellular ther ...

364 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering Finally, as synthetic biologists build increasingly ...

­eferences 365 reactivity, or they may be genetically modified to express disease-targeting receptors prior to expansion and rei ...

366 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering 13 Bovenberg, M.S.S., Degeling, M.H., and Tannous, B ...

­eferences 367 30 Stephan, M.T., Stephan, S.B., Bak, P. et al. (2012) Synapse-directed delivery of immunomodulators using T-cell ...

368 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering 49 Cheng, M., Chen, Y., Xiao, W. et al. (2013) NK ce ...

­eferences 369 64 Gardner, R.A., Finney, O., Annesley, C. et al. (2017) Intent to treat leukemia remission by CD19CAR T cells of ...

370 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering improved homing and antitumor activity in a Hodgkin ...

­eferences 371 96 Zhang, L., Morgan, R.A., Beane, J.D. et al. (2015) Tumor-infiltrating lymphocytes genetically engineered with ...

372 17 Synthetic Biology in Immunotherapy and Stem Cell Therapy Engineering 114 Hasty, J., Dolnik, M., Rottschäfer, V., and Coll ...

373 Societal Ramifications of Synthetic Biology Part V ...

375 Synthetic Biology: Parts, Devices and Applications, First Edition. Edited by Christina Smolke. © 2018 Wiley-VCH Verlag GmbH ...

376 18 Synthetic Biology: From Genetic Engineering 2.0 to Responsible Research and Innovation noncanonical biochemistries [12–17 ...